Tuft Cells and Their Role in Intestinal Diseases.
Crohn’s disease
chemosensing
colorectal neoplasia
inflammation
inflammatory bowel disease
intestine
tuft cells
ulcerative colitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
11
2021
accepted:
25
01
2022
entrez:
3
3
2022
pubmed:
4
3
2022
medline:
3
5
2022
Statut:
epublish
Résumé
The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to helminthic and protozoan infection has further spurred the exploration of these rare chemosensory epithelial cells. Although very sparse in number, tuft cells are now known as important sentinels in the gastrointestinal tract as they monitor intestinal content using succinate as well as sweet and bitter taste receptors. Upon stimulation, tuft cells secrete a broad palette of effector molecules, including interleukin-25, prostaglandin E
Identifiants
pubmed: 35237268
doi: 10.3389/fimmu.2022.822867
pmc: PMC8884241
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
DCLK1 protein, human
EC 2.7.1.11
Doublecortin-Like Kinases
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
822867Informations de copyright
Copyright © 2022 Hendel, Kellermann, Hausmann, Bindslev, Jensen and Nielsen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biochem Biophys Res Commun. 2015 Aug 7;463(4):934-41
pubmed: 26071358
J Infect Dis. 2013 Sep;208(6):917-20
pubmed: 23776194
Cell. 2019 Feb 21;176(5):1158-1173.e16
pubmed: 30712869
Autoimmun Rev. 2017 Jan;16(1):55-63
pubmed: 27697608
Sci Immunol. 2021 Mar 5;6(57):
pubmed: 33674322
Medicine (Baltimore). 2018 Aug;97(34):e12087
pubmed: 30142867
Nat Rev Immunol. 2014 Mar;14(3):141-53
pubmed: 24566914
Gastroenterology. 2009 Aug;137(2):598-606, 606.e1-2
pubmed: 19272386
Biochem Biophys Res Commun. 2020 Dec 17;533(4):704-709
pubmed: 33160623
J Exp Med. 2021 Sep 6;218(9):
pubmed: 34283207
Immunity. 2020 Apr 14;52(4):683-699.e11
pubmed: 32294408
Nature. 2016 Jan 14;529(7585):226-30
pubmed: 26762460
PLoS One. 2017 Dec 7;12(12):e0189340
pubmed: 29216297
Annu Rev Immunol. 2019 Apr 26;37:47-72
pubmed: 30379593
Histochem Cell Biol. 2011 Aug;136(2):191-204
pubmed: 21688022
Cell Rep. 2016 Jul 12;16(2):432-443
pubmed: 27346351
Biomed Res. 2020;41(2):113-118
pubmed: 32307399
J Exp Med. 2006 Apr 17;203(4):1105-16
pubmed: 16606668
J Cell Biol. 2011 Mar 7;192(5):767-80
pubmed: 21383077
J Exp Med. 2022 Jan 3;219(1):
pubmed: 34779829
Cell Tissue Res. 2019 May;376(2):189-197
pubmed: 30666535
Pharmacol Ther. 2014 Aug;143(2):153-67
pubmed: 24603369
PLoS One. 2016 Feb 11;11(2):e0147468
pubmed: 26866366
Aliment Pharmacol Ther. 2013 Aug;38(3):255-63
pubmed: 23730956
Eur J Pediatr Surg. 2020 Feb;30(1):59-63
pubmed: 31707728
Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G792-802
pubmed: 16728727
Front Physiol. 2020 Feb 07;11:32
pubmed: 32116750
Nature. 2018 Jul;559(7715):622-626
pubmed: 30022162
Gastroenterology. 2020 Dec;159(6):2101-2115.e5
pubmed: 32828819
J Exp Med. 2008 Nov 24;205(12):2727-33
pubmed: 19015310
Nat Genet. 2013 Jan;45(1):98-103
pubmed: 23202126
Dig Dis Sci. 2015 May;60(5):1236-46
pubmed: 25666316
Cell Tissue Res. 1979 Sep 2;201(1):37-44
pubmed: 527013
Anaerobe. 2014 Dec;30:205-9
pubmed: 25223264
Sci Rep. 2019 Nov 25;9(1):17466
pubmed: 31767912
Immunity. 2018 Jul 17;49(1):33-41.e7
pubmed: 30021144
J Exp Med. 2007 Feb 19;204(2):253-8
pubmed: 17242164
J Crohns Colitis. 2017 Apr 1;11(4):390-399
pubmed: 27707789
Science. 2016 Mar 18;351(6279):1329-33
pubmed: 26847546
Dev Biol. 2012 Feb 15;362(2):194-218
pubmed: 22185794
Nat Cell Biol. 2018 Aug;20(8):909-916
pubmed: 30038251
Am J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G285-G299
pubmed: 28684459
News Physiol Sci. 2000 Dec;15:284-290
pubmed: 11390928
Inflamm Bowel Dis. 2013 Mar-Apr;19(4):720-8
pubmed: 23429464
Exp Cell Res. 2018 Aug 1;369(1):105-111
pubmed: 29758188
Front Immunol. 2018 May 07;9:987
pubmed: 29867964
Cell Stem Cell. 2018 Jan 4;22(1):35-49.e7
pubmed: 29249464
Sci Rep. 2021 Feb 24;11(1):4509
pubmed: 33627749
Trends Immunol. 2018 Sep;39(9):677-696
pubmed: 29716793
Cell. 2021 Mar 4;184(5):1214-1231.e16
pubmed: 33636133
J Immunol Res. 2018 Sep 23;2018:6519465
pubmed: 30345318
Front Psychiatry. 2020 May 15;11:436
pubmed: 32477197
FASEB J. 2019 Apr;33(4):4907-4920
pubmed: 30629462
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557
pubmed: 29735652
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
Cell. 2013 Jul 18;154(2):274-84
pubmed: 23870119
Nat Neurosci. 2011 Jun;14(6):685-7
pubmed: 21572433
Immunity. 2020 Mar 17;52(3):426-428
pubmed: 32187512
Immunohorizons. 2020 Jan 24;4(1):23-32
pubmed: 31980480
Cell Tissue Res. 2021 Jul;385(1):21-35
pubmed: 33616728
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2392-7
pubmed: 11854532
Immunol Rev. 2008 Dec;226:172-90
pubmed: 19161424
Immunology. 2008 Feb;123(2):197-208
pubmed: 17655740
Mol Metab. 2021 Sep;51:101231
pubmed: 33831593
Nature. 2021 Sep;597(7875):250-255
pubmed: 34497389
BMC Cancer. 2019 Jun 28;19(1):643
pubmed: 31253108
Nature. 2018 Aug;560(7718):377-381
pubmed: 30069046
Front Physiol. 2020 Feb 14;11:88
pubmed: 32116793
Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:26-36
pubmed: 25460828
J Clin Invest. 2014 Mar;124(3):1283-95
pubmed: 24487592
Nature. 2016 Jan 14;529(7585):221-5
pubmed: 26675736
Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G171-7
pubmed: 16710053
J Histochem Cytochem. 2003 Feb;51(2):187-98
pubmed: 12533527
Histochem Cell Biol. 2007 Nov;128(5):457-71
pubmed: 17874119
Front Immunol. 2021 May 28;12:629391
pubmed: 34122403
Front Physiol. 2017 Oct 30;8:849
pubmed: 29163195
Eur J Gastroenterol Hepatol. 2021 Jun 1;33(6):817-824
pubmed: 33079783
J Histochem Cytochem. 2017 Jun;65(6):347-366
pubmed: 28375676
Science. 2018 Apr 13;360(6385):204-208
pubmed: 29650672
Cell. 2018 Jul 12;174(2):271-284.e14
pubmed: 29887373
Nat Rev Dis Primers. 2020 Sep 10;6(1):74
pubmed: 32913180
Cell Tissue Res. 1990 Nov;262(2):339-49
pubmed: 2076538
Sci Immunol. 2021 Mar 5;6(57):
pubmed: 33674321
Epidemiol Infect. 2015 Jun;143(8):1710-7
pubmed: 25336060
J Exp Med. 2007 Jan 22;204(1):161-70
pubmed: 17200411
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Front Pharmacol. 2020 Nov 30;11:587664
pubmed: 33390961
Trends Parasitol. 2011 May;27(5):214-21
pubmed: 21292555
Nat Rev Dis Primers. 2020 Apr 2;6(1):22
pubmed: 32242028
Dig Dis Sci. 2017 Oct;62(10):2768-2779
pubmed: 28667430
JCI Insight. 2017 Jun 2;2(11):
pubmed: 28570279
Sci Rep. 2017 May 10;7(1):1652
pubmed: 28490731
Int J Mol Sci. 2020 Jul 21;21(14):
pubmed: 32708215
J Comp Neurol. 2008 Aug 10;509(5):514-25
pubmed: 18537122
Nat Rev Cancer. 2010 Mar;10(3):181-93
pubmed: 20168319
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6075-80
pubmed: 24711432
APMIS. 2016 Nov;124(11):958-965
pubmed: 27677532
Immunity. 2020 Mar 17;52(3):528-541.e7
pubmed: 32160525
FASEB J. 2020 Jan;34(1):316-332
pubmed: 31914675
Nature. 2020 Apr;580(7804):524-529
pubmed: 32322056
Mol Carcinog. 2017 Oct;56(10):2223-2233
pubmed: 28544328
Curr Opin Genet Dev. 2021 Oct;70:40-47
pubmed: 34062491
J Clin Invest. 2000 Oct;106(8):1053-60
pubmed: 11032865
Cell Res. 2020 Aug;30(8):635-636
pubmed: 32494022
Nature. 2017 Nov 16;551(7680):333-339
pubmed: 29144463
Chem Senses. 2007 Jan;32(1):41-9
pubmed: 17030556
Am J Gastroenterol. 2003 Sep;98(9):2034-41
pubmed: 14499784
N Engl J Med. 2020 Dec 31;383(27):2652-2664
pubmed: 33382932
Curr Opin Immunol. 2021 Feb;68:98-106
pubmed: 33166855
Cell Tissue Res. 2010 Mar;339(3):493-504
pubmed: 20063013
Nat Commun. 2021 Feb 5;12(1):836
pubmed: 33547321
Inflamm Bowel Dis. 2007 Nov;13(11):1347-56
pubmed: 17663429
Front Physiol. 2015 Mar 24;6:87
pubmed: 25852573
Baillieres Clin Gastroenterol. 1988 Jan;2(1):123-39
pubmed: 2838107
Z Zellforsch Mikrosk Anat. 1956;44(4):345-412
pubmed: 13353477
Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5564-5569
pubmed: 30819885
Gastroenterology. 2011 May;140(6):1756-1767
pubmed: 21530742
Nat Commun. 2020 Jan 8;11(1):111
pubmed: 31913277
Cell Mol Life Sci. 2018 Jan;75(1):49-65
pubmed: 28801754
Cell Tissue Res. 2014 Dec;358(3):737-48
pubmed: 25300645
Curr Protoc. 2021 Mar;1(3):e77
pubmed: 33740294
Nature. 2018 Aug;560(7718):319-324
pubmed: 30069044
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6631-4
pubmed: 8692869
Drug Metab Dispos. 2014 Dec;42(12):2016-22
pubmed: 25233858
Am J Gastroenterol. 1997 Jul;92(7):1170-3
pubmed: 9219792
J Exp Clin Cancer Res. 2019 Jul 11;38(1):303
pubmed: 31296243
Cell Syst. 2018 Jan 24;6(1):37-51.e9
pubmed: 29153838