A population-based study in resected esophageal or gastroesophageal junction cancer aligned with CheckMate 577.

BACKGROUND

Results of CheckMate 577 show an improved disease-free survival for patients with resected esophageal or gastroesophageal junction cancer treated with adjuvant nivolumab compared with placebo (22.4

PATIENTS AND METHODS

Resected patients with stage II/III esophageal or gastroesophageal junction cancer (2015-2016) treated with neoadjuvant chemoradiotherapy were selected from the Netherlands Cancer Registry. Patients with cervical esophageal cancer, irradical resection, or complete pathological response were excluded. Disease-free and overall survival were assessed from 12 weeks after resection using Kaplan-Meier methods. In addition, to adjust for differences in characteristics between CheckMate 577 and our population-based cohort, a matching-adjusted indirect comparison was performed for pathological lymph node status and pathological tumor status.

RESULTS

We identified 634 patients. Sixty percent of patients were diagnosed with recurrence or were deceased at the end of follow-up. Median disease-free survival was 19.7 months and median overall survival was 32.2 months. After the matching procedure, the median disease-free survival was 17.2 months and median overall survival was 28.2 months.

CONCLUSIONS

Disease-free survival in our population-based study was considerably longer than the placebo population of CheckMate-577 (19.7

Informations de copyright

© The Author(s), 2022.

Déclaration de conflit d'intérêts

Conflict of interest statement: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: MIvBH reports unrestricted research grants from Stryker and Olympus with fees paid to the institution and an advisory role for Johnson & Johnson, BBraun Alesi Surgical, Mylan, and Medtronic. MM reports grants and nonfinancial support from Arbeitsgemeinschaft Internistische Onkologie, German Ministry of Education and Research, the European Organisation for Research and Treatment of Cancer, and German Cancer Aid during the conduct of the study; personal fees from Amgen, Bristol Myers Squibb, Falk Foundation, Lilly, MCI Group, Merck Serono, Merck Sharp & Dohme Corp., Pfizer, and Roche; grants to the university from Amgen, Bristol Myers Squibb, Merck Serono, Merck Sharp & Dohme Corp., and Pfizer; and nonfinancial support from Amgen and Bristol Myers Squibb outside the submitted work. HWMvL reports grants from Roche; has served as a consultant for Bristol Myers Squibb, Celgene, Lilly, and Nordic; and has received unrestricted research funding from Bayer, Bristol Myers Squibb, Celgene, Lilly, Merck Serono, MSD, Nordic, Philips, and Roche. RHAV reports grants from Bristol Myers Squibb and Roche. MP, PAJV, LVB, SML, and SM have no disclosures to declare.