Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments.
Cognition
Depression
Generation Scotland
Longitudinal
Neuroimaging
Psychological resilience
Journal
Wellcome open research
ISSN: 2398-502X
Titre abrégé: Wellcome Open Res
Pays: England
ID NLM: 101696457
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
10
06
2021
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
5
3
2022
Statut:
epublish
Résumé
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
Identifiants
pubmed: 35237729
doi: 10.12688/wellcomeopenres.15538.2
pmc: PMC8857525
doi:
Types de publication
Journal Article
Langues
eng
Pagination
185Subventions
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_MR/R01910X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035818/1
Pays : United Kingdom
Informations de copyright
Copyright: © 2021 Habota T et al.
Déclaration de conflit d'intérêts
Competing interests: ISP-V and MRM are co-directors of Jericoe Ltd, a company that designs software for the assessment and modification of emotion recognition.
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