Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study.
ARDS
COVID-19
ECMO
Severe respiratory failure
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
29
11
2021
accepted:
07
02
2022
pubmed:
4
3
2022
medline:
30
3
2022
entrez:
3
3
2022
Statut:
ppublish
Résumé
Extracorporeal membrane oxygenation (ECMO) has become an established therapy for severe respiratory failure in coronavirus disease 2019 (COVID-19). The added benefit of receiving ECMO in COVID-19 remains uncertain. The aim of this study is to analyse the impact of receiving ECMO at specialist centres on hospital mortality. A multi-centre retrospective study was conducted in COVID-19 patients from 111 hospitals, referred to two specialist ECMO centres in the United Kingdom (UK) (March 2020 to February 2021). Detailed covariate data were contemporaneously curated from electronic referral systems. We analysed added benefit of ECMO treatment in specialist centres using propensity score matching techniques. 1363 patients, 243 receiving ECMO, were analysed. The best matching technique generated 209 matches, with a marginal odds ratio (OR) for mortality of 0.44 (95% CI 0.29-0.68, p < 0.001) and absolute mortality reduction of 18.2% (44% vs 25.8%, p < 0.001) for treatment with ECMO in a specialist centre. We found ECMO provided at specialist centres conferred significant survival benefit. Where resources and specialism allow, ECMO should be widely offered.
Identifiants
pubmed: 35238946
doi: 10.1007/s00134-022-06645-w
pii: 10.1007/s00134-022-06645-w
pmc: PMC8892395
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-478Commentaires et corrections
Type : ErratumIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.
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