Overview of polymyxin resistance in Enterobacteriaceae.
Journal
Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 1678-9849
Titre abrégé: Rev Soc Bras Med Trop
Pays: Brazil
ID NLM: 7507456
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
07
2021
accepted:
12
11
2021
entrez:
3
3
2022
pubmed:
4
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
Identifiants
pubmed: 35239902
pii: S0037-86822022000100250
doi: 10.1590/0037-8682-0349-2021
pmc: PMC8909443
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Polymyxins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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