Functional Impairment and Periodontitis in Rheumatoid Arthritis.
Epidemiology
Functional impairment
Periodontitis
Rheumatoid arthritis
Serum MMP-3
Journal
International dental journal
ISSN: 1875-595X
Titre abrégé: Int Dent J
Pays: England
ID NLM: 0374714
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
22
10
2021
revised:
18
01
2022
accepted:
19
01
2022
pubmed:
5
3
2022
medline:
20
9
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
This study explored the association of functional impairment due to rheumatoid arthritis (RA) and RA disease activity with periodontal disease in patients with RA. Ninety-three patients with RA were included. Their RA functional status was assessed using the Steinbrocker classification. The serum level of matrix metalloproteinase-3 (MMP-3) was used as an indicator of RA disease activity. Probing depth (PD) and clinical attachment level (CAL) were used as indicators of periodontal status. We examined the association of RA severity and MMP-3 levels with periodontal status using a generalised linear model (GLM). In a multivariate GLM, the coefficient for the mean PD was significantly positive in those with RA severity classes III or IV (reference: class I; β = 0.14; 95% confidence interval [CI], 0.03-0.25; P = .02) independent of other confounding variables. In multivariate GLM using the mean CAL as the dependent variable, the coefficient was significant in patients with high MMP-3 levels (10 ng/mL; β = 0.005; 95% CI, 0.001-0.008; P = .02). Functional impairment due to RA may affect PD, and high serum levels of MMP-3 may affect CAL.
Sections du résumé
BACKGROUND
BACKGROUND
This study explored the association of functional impairment due to rheumatoid arthritis (RA) and RA disease activity with periodontal disease in patients with RA.
METHODS
METHODS
Ninety-three patients with RA were included. Their RA functional status was assessed using the Steinbrocker classification. The serum level of matrix metalloproteinase-3 (MMP-3) was used as an indicator of RA disease activity. Probing depth (PD) and clinical attachment level (CAL) were used as indicators of periodontal status. We examined the association of RA severity and MMP-3 levels with periodontal status using a generalised linear model (GLM).
RESULTS
RESULTS
In a multivariate GLM, the coefficient for the mean PD was significantly positive in those with RA severity classes III or IV (reference: class I; β = 0.14; 95% confidence interval [CI], 0.03-0.25; P = .02) independent of other confounding variables. In multivariate GLM using the mean CAL as the dependent variable, the coefficient was significant in patients with high MMP-3 levels (10 ng/mL; β = 0.005; 95% CI, 0.001-0.008; P = .02).
CONCLUSIONS
CONCLUSIONS
Functional impairment due to RA may affect PD, and high serum levels of MMP-3 may affect CAL.
Identifiants
pubmed: 35241287
pii: S0020-6539(22)00022-3
doi: 10.1016/j.identj.2022.01.002
pmc: PMC9485534
pii:
doi:
Substances chimiques
Matrix Metalloproteinase 3
EC 3.4.24.17
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-647Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest None disclosed.
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