Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
12
02
2021
accepted:
17
12
2021
pubmed:
5
3
2022
medline:
15
4
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID-19). Here, through a genome-wide association study, we identify a variant (rs190509934, minor allele frequency 0.2-2%) that downregulates ACE2 expression by 37% (P = 2.7 × 10
Identifiants
pubmed: 35241825
doi: 10.1038/s41588-021-01006-7
pii: 10.1038/s41588-021-01006-7
pmc: PMC9005345
doi:
Substances chimiques
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
382-392Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001878
Pays : United States
Investigateurs
Gonçalo Abecasis
(G)
Michael Cantor
(M)
Giovanni Coppola
(G)
Andrew Deubler
(A)
Aris Economides
(A)
Katia Karalis
(K)
Luca A Lotta
(LA)
Alan Shuldiner
(A)
Christina Beechert
(C)
Caitlin Forsythe
(C)
Erin D Fuller
(ED)
Zhenhua Gu
(Z)
Michael Lattari
(M)
Alexander Lopez
(A)
Maria Sotiropoulos Padilla
(MS)
Manasi Pradhan
(M)
Kia Manoochehri
(K)
Thomas D Schleicher
(TD)
Louis Widom
(L)
Sarah E Wolf
(SE)
Ricardo H Ulloa
(RH)
Amelia Averitt
(A)
Dadong Li
(D)
Sameer Malhotra
(S)
Jeffrey Staples
(J)
Suying Bao
(S)
Boris Boutkov
(B)
Siying Chen
(S)
Gisu Eom
(G)
Alicia Hawes
(A)
Shareef Khalid
(S)
Olga Krasheninina
(O)
Rouel Lanche
(R)
Evan K Maxwell
(EK)
George Mitra
(G)
Mona Nafde
(M)
Sean O'Keeffe
(S)
Max Orelus
(M)
Razvan Panea
(R)
Tommy Polanco
(T)
Ayesha Rasool
(A)
Jeffrey G Reid
(JG)
William Salerno
(W)
Jeffrey C Staples
(JC)
Kathie Sun
(K)
Jiwen Xin
(J)
Joshua Backman
(J)
Manuel Allen Revez Ferreira
(MAR)
Arkopravo Ghosh
(A)
Christopher Gillies
(C)
Eric Jorgenson
(E)
Hyun Min Kang
(HM)
Michael Kessler
(M)
Alexander Li
(A)
Nan Lin
(N)
Daren Liu
(D)
Adam Locke
(A)
Arden Moscati
(A)
Charles Paulding
(C)
Carlo Sidore
(C)
Bin Ye
(B)
Blair Zhang
(B)
Andrey Ziyatdinov
(A)
Ariane Ayer
(A)
Aysegul Guvenek
(A)
George Hindy
(G)
Jan Freudenberg
(J)
Jonas Bovijn
(J)
Julie E Horowitz
(JE)
Kavita Praveen
(K)
Manav Kapoor
(M)
Mary Haas
(M)
Moeen Riaz
(M)
Niek Verweij
(N)
Olukayode Sosina
(O)
Parsa Akbari
(P)
Priyanka Nakka
(P)
Sahar Gelfman
(S)
Sujit Gokhale
(S)
Tanima De
(T)
Veera Rajagopal
(V)
Gannie Tzoneva
(G)
Juan Rodriguez-Flores
(J)
Shek Man Chim
(SM)
Valerio Donato
(V)
Daniel Fernandez
(D)
Giusy Della Gatta
(GD)
Alessandro Di Gioia
(A)
Kristen Howell
(K)
Lori Khrimian
(L)
Minhee Kim
(M)
Hector Martinez
(H)
Lawrence Miloscio
(L)
Sheilyn Nunez
(S)
Elias Pavlopoulos
(E)
Trikaldarshi Persaud
(T)
Esteban Chen
(E)
Marcus B Jones
(MB)
Michelle G LeBlanc
(MG)
Jason Mighty
(J)
Lyndon J Mitnaul
(LJ)
Nirupama Nishtala
(N)
Nadia Rana
(N)
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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