The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish.
Behavioral neuroscience
Biological sciences
Molecular neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
27
07
2021
revised:
16
12
2021
accepted:
01
02
2022
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
5
3
2022
Statut:
epublish
Résumé
Behavior is context-dependent and often modulated by an animal's internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is regulated by the presence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social behavior paradigms. Here, we show that the propensity to react to sudden stimuli with an escape response was increased in
Identifiants
pubmed: 35243231
doi: 10.1016/j.isci.2022.103868
pii: S2589-0042(22)00138-9
pmc: PMC8861652
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103868Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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