Tertiary lymphoid structure and decreased CD8

Cancer Components of the immune system Immunity

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
18 Mar 2022
Historique:
received: 05 10 2021
revised: 03 12 2021
accepted: 02 02 2022
entrez: 4 3 2022
pubmed: 5 3 2022
medline: 5 3 2022
Statut: epublish

Résumé

Knowledge of the tumor microenvironment (TME) in patients with early lung cancer, especially in comparison with the matched adjacent tissues, remains lacking. To characterize TME of early-stage lung adenocarcinoma, we performed RNA-seq profiling on 58 pairs of minimally invasive adenocarcinoma (MIA) tumors and matched adjacent normal tissues. MIA tumors exhibited an adaptive TME characterized by high CD4

Identifiants

pubmed: 35243243
doi: 10.1016/j.isci.2022.103883
pii: S2589-0042(22)00153-5
pmc: PMC8873609
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103883

Informations de copyright

© 2022 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Jin Wang (J)

Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Dongbo Jiang (D)

Department of Immunology, School of Basic Medicine, Air-Force Medical University (Fourth Military Medical University), Xi'an, China.

Xiaoqi Zheng (X)

Department of Mathematics, Shanghai Normal University, Shanghai, China.

Wang Li (W)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Life Sciences and Technology, Shanghai, China.

Tian Zhao (T)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Life Sciences and Technology, Shanghai, China.

Di Wang (D)

Tissue Bank, Department of Pathology, Experimental Animal Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Huansha Yu (H)

Tissue Bank, Department of Pathology, Experimental Animal Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Dongqing Sun (D)

Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Ziyi Li (Z)

Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Jian Zhang (J)

Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.

Zhe Zhang (Z)

Department of Gynecologic Oncology, Chinese PLA General Hospital, Beijing, China.

Likun Hou (L)

Tissue Bank, Department of Pathology, Experimental Animal Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Gening Jiang (G)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Ke Fei (K)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Fan Zhang (F)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Life Sciences and Technology, Shanghai, China.

Kun Yang (K)

Department of Immunology, School of Basic Medicine, Air-Force Medical University (Fourth Military Medical University), Xi'an, China.

Peng Zhang (P)

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Classifications MeSH