Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli.
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
received:
28
08
2021
revised:
29
10
2021
accepted:
16
01
2022
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Tailored skin microbiome modulation approaches with probiotics are highly challenging. Here, we show that lactobacilli are underestimated members of the skin microbiota. We select specific strains of nomadic lactobacilli for their functional applicability on the skin and capacity to inhibit growth and inflammation by skin pathobionts. The strains are formulated as microcapsules for topical formulations and tested in patients with mild-to-moderate acne. The selected lactobacilli are able to reduce inflammatory lesions in a pilot and placebo-controlled study. Daily application for 8 weeks is associated with an
Identifiants
pubmed: 35243421
doi: 10.1016/j.xcrm.2022.100521
pii: S2666-3791(22)00021-0
pmc: PMC8861818
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100521Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
YUN NV (www.yun.be) was funded as a biotech company focusing on probiotics for the skin after the scientific studies mentioned in this paper. I.C. and T.H. were employed at the University of Antwerp at the time of the study but are currently working at the R&D Department of YUN (www.yun.be). I.C. is now Chief Scientific Officer of YUN NV. T.H. is R&D manager of YUN NV. S.L. and J.L. are members of the scientific advisory board of YUN NV. I.C., T.H., and S.L. are minority stakeholders of YUN. The PhD research of L.D. is currently funded by VLAIO through a Baekeland mandate in collaboration with YUN NV. Based on the data presented here, YUN NV has selected and formulated three Lactobacillus strains: L. pentosus YUN-V1.0, L. plantarum YUN-V2.0, and L. rhamnosus YUN-S1.0 in their commercial ACN product. Patents related to this work include dermatological preparations for maintaining and/or restoring healthy skin microbiota (WO2017220525A1) and preservation of micro-organisms (WO2018002248). The remaining authors have no conflicts of interest to declare.
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