Pharmacological inhibition of acetylcholine-regulated potassium current (
Atrial fibrillation
Cholinergic activation
IK,ACh
Rats
Sleep apnea
Journal
Heart rhythm O2
ISSN: 2666-5018
Titre abrégé: Heart Rhythm O2
Pays: United States
ID NLM: 101768511
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
5
3
2022
Statut:
epublish
Résumé
In obstructive sleep apnea (OSA), intermittent hypoxemia and intrathoracic pressure fluctuations may increase atrial fibrillation (AF) susceptibility by cholinergic activation. To investigate short-term atrial electrophysiological consequences of obstructive respiratory events, simulated by intermittent negative upper airway pressure (INAP), and the role of atrial acetylcholine-regulated potassium current ( In sedated (2% isoflurane), spontaneously breathing rats, INAP was applied noninvasively by a negative pressure device for 1 minute, followed by a resting period of 4 minutes. INAP was applied repeatedly throughout 70 minutes, followed by a 2-hour recovery period. Atrial effective refractory period (AERP) and AF inducibility were determined throughout the protocol. To study INAP-induced In vehicle-treated rats, repetitive INAP shortened AERP (37 ± 3 ms vs baseline 44 ± 3 ms; Short-term simulated OSA is associated with a progressive, but transient, AERP shortening and a PKC
Sections du résumé
BACKGROUND
BACKGROUND
In obstructive sleep apnea (OSA), intermittent hypoxemia and intrathoracic pressure fluctuations may increase atrial fibrillation (AF) susceptibility by cholinergic activation.
OBJECTIVE
OBJECTIVE
To investigate short-term atrial electrophysiological consequences of obstructive respiratory events, simulated by intermittent negative upper airway pressure (INAP), and the role of atrial acetylcholine-regulated potassium current (
METHODS
METHODS
In sedated (2% isoflurane), spontaneously breathing rats, INAP was applied noninvasively by a negative pressure device for 1 minute, followed by a resting period of 4 minutes. INAP was applied repeatedly throughout 70 minutes, followed by a 2-hour recovery period. Atrial effective refractory period (AERP) and AF inducibility were determined throughout the protocol. To study INAP-induced
RESULTS
RESULTS
In vehicle-treated rats, repetitive INAP shortened AERP (37 ± 3 ms vs baseline 44 ± 3 ms;
CONCLUSION
CONCLUSIONS
Short-term simulated OSA is associated with a progressive, but transient, AERP shortening and a PKC
Identifiants
pubmed: 35243441
doi: 10.1016/j.hroo.2021.11.013
pii: S2666-5018(21)00223-3
pmc: PMC8859790
doi:
Types de publication
Journal Article
Langues
eng
Pagination
97-104Informations de copyright
© 2021 Heart Rhythm Society. Published by Elsevier Inc.
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