Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 03 2022
04 03 2022
Historique:
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
20
4
2022
Statut:
ppublish
Résumé
Schizophrenia (SCZ) is a chronic, serious mental disorder. Although more than 200 SCZ-associated genes have been identified, the underlying molecular and cellular mechanisms remain largely unknown. Here, we generated a Setd1a (SET domain containing 1A) haploinsufficiency mouse model to understand how this SCZ-associated epigenetic factor affects gene expression in brain regions highly relevant to SCZ. Single-cell RNA sequencing revealed that Setd1a heterozygosity causes highly variable transcriptional adaptations across different cell types in prefrontal cortex (PFC) and striatum. The
Identifiants
pubmed: 35245111
doi: 10.1126/sciadv.abm1077
pmc: PMC8896793
doi:
Substances chimiques
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Nsccn1 protein, mouse
EC 2.1.1.43
Setd1A protein, human
EC 2.1.1.43
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabm1077Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042283
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA050589
Pays : United States
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