Association between risk of obstructive sleep apnea, inflammation and cognition after 45 years old in the Canadian Longitudinal Study on Aging.

Aging C-Reactive Protein Canada / epidemiology Cognition Female Humans Inflammation / complications Longitudinal Studies Male Memory Disorders / complications Middle Aged Sleep Apnea, Obstructive / complications
Aging C-reactive protein Cognition Sleep-disordered breathing

Journal

Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759

Informations de publication

Date de publication:
03 2022
Historique:
received: 09 12 2021
revised: 01 02 2022
accepted: 07 02 2022
pubmed: 5 3 2022
medline: 27 4 2022
entrez: 4 3 2022
Statut: ppublish

Résumé

The association between obstructive sleep apnea and cognitive functioning is not yet fully understood and could be influenced by factors such as sex, age and systemic inflammation. We determined the sex- and age-specific association between obstructive sleep apnea risk and cognitive performance, and the influence of systemic inflammation on this association. We included 25,899 participants from the Canadian Longitudinal Study of Aging comprehensive cohort, aged 45-85 years (51% women). We conducted sex- and age-specific (45-59; 60-69; ≥70) general linear models between obstructive sleep apnea risk and cognitive scores, and tested the moderating and mediating effects of high-sensitivity C-reactive protein levels. Obstructive sleep apnea risk was estimated by combining the STOP and whole-body fat percentage. Cognitive tests assessed episodic verbal memory, executive functions and psychomotor speed. Levels of high-sensitivity C-reactive protein were obtained through blood samples. Higher obstructive sleep apnea risk was associated with poorer episodic memory in women aged 45-59 years, and poorer executive function (p < 0.05 on multiple tests) in women aged 45-59 and 60-69 years. No such association was found in men. High-sensitivity C-reactive protein levels mediated some associations between obstructive sleep apnea risk and executive function in women and men aged <70 years. Being at high-risk for obstructive sleep apnea is associated with poorer cognition in women aged <70 years. These associations were partly mediated by systemic inflammation. These results underscore the importance of obstructive sleep apnea diagnosis, treatment and appropriate follow-up, particularly in middle-aged women who might already show signs of early cognitive impairments.

Sections du résumé

BACKGROUND
The association between obstructive sleep apnea and cognitive functioning is not yet fully understood and could be influenced by factors such as sex, age and systemic inflammation. We determined the sex- and age-specific association between obstructive sleep apnea risk and cognitive performance, and the influence of systemic inflammation on this association.
METHODS
We included 25,899 participants from the Canadian Longitudinal Study of Aging comprehensive cohort, aged 45-85 years (51% women). We conducted sex- and age-specific (45-59; 60-69; ≥70) general linear models between obstructive sleep apnea risk and cognitive scores, and tested the moderating and mediating effects of high-sensitivity C-reactive protein levels. Obstructive sleep apnea risk was estimated by combining the STOP and whole-body fat percentage. Cognitive tests assessed episodic verbal memory, executive functions and psychomotor speed. Levels of high-sensitivity C-reactive protein were obtained through blood samples.
RESULTS
Higher obstructive sleep apnea risk was associated with poorer episodic memory in women aged 45-59 years, and poorer executive function (p < 0.05 on multiple tests) in women aged 45-59 and 60-69 years. No such association was found in men. High-sensitivity C-reactive protein levels mediated some associations between obstructive sleep apnea risk and executive function in women and men aged <70 years.
CONCLUSIONS
Being at high-risk for obstructive sleep apnea is associated with poorer cognition in women aged <70 years. These associations were partly mediated by systemic inflammation. These results underscore the importance of obstructive sleep apnea diagnosis, treatment and appropriate follow-up, particularly in middle-aged women who might already show signs of early cognitive impairments.

Identifiants

DOI: 10.1016/j.sleep.2022.02.006 PMID: 35245788
pubmed: 35245788
pii: S1389-9457(22)00049-1
doi: 10.1016/j.sleep.2022.02.006
pii:
doi:

Substances chimiques

C-Reactive Protein 9007-41-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

21-30

Subventions

Organisme : CIHR
ID : LSA 94473
Pays : Canada
Organisme : CIHR
ID : CDT-142656
Pays : Canada
Organisme : CIHR
ID : FDN154291
Pays : Canada

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Cynthia Thompson (C)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada.

Julie Legault (J)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; Department of Psychology, Université de Montréal, 90 Vincent d'Indy Avenue, Montreal, QC H2V 2S9, Canada.

Gregory Moullec (G)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; École de santé publique, Département de Médecine Sociale et Préventive, Université de Montréal, 7101 Parc Avenue, Montreal, QC H3N 1X7, Canada.

Marie-Ève Martineau-Dussault (MÈ)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; Department of Psychology, Université de Montréal, 90 Vincent d'Indy Avenue, Montreal, QC H2V 2S9, Canada.

Marc Baltzan (M)

Mount Sinai Hospital Center, 5690 boul Cavendish, Montreal, QC H4W 1S7, Canada; Department of Epidemiology and Biostatistics, Faculty of Medicine, McGill University, 3605 De la Montagne Street, Montreal, QC H3G 2M1, Canada.

Nathan Cross (N)

Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS du Centre-Sud-de-l'Ile-de-Montréal, 4565 Queen-Mary Road, Montreal, QC H3W 1W5, Canada; Center for Studies in Behavioral Neurobiology, Department of Health, Kinesiology and Applied Physiology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada.

Thien Thanh Dang-Vu (TT)

Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS du Centre-Sud-de-l'Ile-de-Montréal, 4565 Queen-Mary Road, Montreal, QC H3W 1W5, Canada; Center for Studies in Behavioral Neurobiology, Department of Health, Kinesiology and Applied Physiology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada.

Nicole Gervais (N)

Rotman Research Institute, Baycrest Health Sciences, 3560 Bathurst Street, North York, ON M6A 2E1, Canada.

Gillian Einstein (G)

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON M5S 3G3, Canada.

Patrick Hanly (P)

Sleep Centre, Foothills Medical Centre, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada.

Najib Ayas (N)

Department of Medicine, University of British Columbia, 317 - 2194 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada; Leon Judah Blackmore Sleep Disorders Program, University of British Columbia Hospital, 2211 Wesbrook Mall UBC Hospital, Vancouver, BC V6T 2B5, Canada.

Dominique Lorrain (D)

Research Centre on Aging, University Institute of Geriatrics of Sherbrooke, CIUSSS de l'Estrie - CHUS, 1036 Belvédère Street South, Sherbrooke, QC J1H 4C4, Canada; University of Sherbrooke, 2500 Université Boulevard, Sherbrooke, QC J1K 2R1, Canada.

Marta Kaminska (M)

Respiratory Epidemiology and Clinical Research Unit, Respiratory Division and Sleep Laboratory, Department of Medicine, McGill University Health Center, 3605 De la Montagne Street, Montreal, QC H3G 2M1, Canada.

Jean-François Gagnon (JF)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; Department of Psychology, Université du Québec à Montréal, 100 Sherbrooke Street Ouest, Montreal, QC H2X 3P2, Canada.

Andrew Lim (A)

LC Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; Department of Medicine, Division of Neurology, University of Toronto, 6 Queen's Park Crescent West, Toronto, ON M5S 3H2, Canada.

Julie Carrier (J)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; Department of Psychology, Université de Montréal, 90 Vincent d'Indy Avenue, Montreal, QC H2V 2S9, Canada.

Nadia Gosselin (N)

Research Center, CIUSSS Nord-de-l'Ile-de-Montréal, 5400 Gouin Street West, Montreal, QC H4J 1C5, Canada; Department of Psychology, Université de Montréal, 90 Vincent d'Indy Avenue, Montreal, QC H2V 2S9, Canada. Electronic address: nadia.gosselin@umontreal.ca.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Association between risk of obstructive sleep...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéine C-réactive › Association between risk of obstructive sleep...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › Canada › Association between risk of obstructive sleep...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Association between risk of obstructive sleep...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association between risk of obstructive sleep...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Association between risk of obstructive sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Association between risk of obstructive sleep...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Association between risk of obstructive sleep...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Association between risk of obstructive sleep...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Association between risk of obstructive sleep...