Light-activated receptor tyrosine kinases: Designs and applications.

Animals Humans Ligands Receptor Protein-Tyrosine Kinases / metabolism Signal Transduction Tyrosine

Journal

Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133

Informations de publication

Date de publication:
04 2022
Historique:
received: 17 10 2021
revised: 28 01 2022
accepted: 30 01 2022
pubmed: 5 3 2022
medline: 12 4 2022
entrez: 4 3 2022
Statut: ppublish

Résumé

Receptor tyrosine kinases (RTKs) are a large and essential membrane receptor family. The molecular mechanisms and physiological consequences of RTK activation depend on, for example, ligand identity, subcellular localization, and developmental or disease stage. In the past few years, genetically-encoded light-activated RTKs (Opto-RTKs) have been developed to dissect these complexities by providing reversible and spatio-temporal control over cell signaling. These methods have very recently matured to include highly-sensitive multi-color actuators. The new ability to regulate RTK activity with high precision has been recently harnessed to gain mechanistic insights in subcellular, tissue, and animal models. Because of their sophisticated engineering, Opto-RTKs may only mirror some aspects of natural activation mechanisms but nevertheless offer unique opportunities to study RTK signaling and physiology.

Identifiants

DOI: 10.1016/j.coph.2022.102197 PMID: 35245796
pubmed: 35245796
pii: S1471-4892(22)00023-6
doi: 10.1016/j.coph.2022.102197
pii:
doi:

Substances chimiques

Ligands 0
Tyrosine 42HK56048U
Receptor Protein-Tyrosine Kinases EC 2.7.10.1

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102197

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Samuel H Crossman (SH)

Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 15 Innovation Walk, Clayton, Victoria 3800, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 15 Innovation Walk, Clayton, Victoria 3800, Australia.

Harald Janovjak (H)

Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 15 Innovation Walk, Clayton, Victoria 3800, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 15 Innovation Walk, Clayton, Victoria 3800, Australia; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia. Electronic address: harald.janovjak@flinders.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Light-activated receptor tyrosine kinases:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Light-activated receptor tyrosine kinases:...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Light-activated receptor tyrosine kinases:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Light-activated receptor tyrosine kinases:...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Light-activated receptor tyrosine kinases:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Tyrosine › Light-activated receptor tyrosine kinases:...