Modular polymer platform as a novel approach to head and neck cancer therapy.

Animals Chemoradiotherapy, Adjuvant Head and Neck Neoplasms / therapy Humans Mice Polymers / chemistry Quality of Life

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
04 03 2022
Historique:
received: 15 11 2021
accepted: 14 02 2022
entrez: 5 3 2022
pubmed: 6 3 2022
medline: 15 4 2022
Statut: epublish

Résumé

Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.

Identifiants

DOI: 10.1038/s41598-022-07324-y PMID: 35246558 PMC: PMC8897426
pubmed: 35246558
doi: 10.1038/s41598-022-07324-y
pii: 10.1038/s41598-022-07324-y
pmc: PMC8897426
doi:

Substances chimiques

Polymers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3592

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Yazeed Alhiyari (Y)

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA.

Jundong Shao (J)

Department of Bioengineering, University of California Los Angeles, Los Angeles, CS, USA.

Albert Y Han (AY)

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA.
Jonsson Comprehensive Cancer Center, University of Los Angeles Medical Center, Los Angeles, CA, USA.
David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.

Amanda Miller (A)

David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.

Jeffrey F Krane (JF)

Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA, USA.

Marie Luff (M)

David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.

Milica Momcilovic (M)

DGSOM Division of Pulmonary and Critical Care Medicine, Head and Neck Cancer Program, University of Los Angeles, Los Angeles, CA, USA.

David Shackelford (D)

Jonsson Comprehensive Cancer Center, University of Los Angeles Medical Center, Los Angeles, CA, USA.
DGSOM Division of Pulmonary and Critical Care Medicine, Head and Neck Cancer Program, University of Los Angeles, Los Angeles, CA, USA.

Zhen Gu (Z)

Department of Bioengineering, University of California Los Angeles, Los Angeles, CS, USA. ZhenGu@g.ucla.edu.

Maie A St John (MAS)

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA. MStJohn@mednet.ucla.edu.
Jonsson Comprehensive Cancer Center, University of Los Angeles Medical Center, Los Angeles, CA, USA. MStJohn@mednet.ucla.edu.
DGSOM Division of Pulmonary and Critical Care Medicine, Head and Neck Cancer Program, University of Los Angeles, Los Angeles, CA, USA. MStJohn@mednet.ucla.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Modular polymer platform as a novel approach...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Chimioradiothérapie › Chimioradiothérapie adjuvante › Modular polymer platform as a novel approach...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Modular polymer platform as a novel approach...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modular polymer platform as a novel approach...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Modular polymer platform as a novel approach...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Modular polymer platform as a novel approach...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Modular polymer platform as a novel approach...