Immunogenicity of ChAdOx1 nCoV-19 vaccine after a two-dose inactivated SARS-CoV-2 vaccination of dialysis patients and kidney transplant recipients.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2022
04 03 2022
Historique:
received:
24
11
2021
accepted:
22
02
2022
entrez:
5
3
2022
pubmed:
6
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Vaccination with inactivated SARS-CoV-2 virus produces suboptimal immune responses among kidney transplant (KT), peritoneal dialyzed (PD), and hemodialyzed (HD) patients. Participants were vaccinated with two-dose inactivated SARS-CoV-2 vaccine (V2) and a third dose of ChAdOx1 nCoV-19 vaccine (V3) at 1-2 months after V2. We enrolled 106 participants: 31 KT, 28 PD, and 31 HD patients and 16 controls. Among KT, PD, and HD groups, median (IQR) of anti-receptor binding domain antibody levels were 1.0 (0.4-26.8), 1092.5 (606.9-1927.2), and 1740.9 (1106-3762.3) BAU/mL, and percent neutralization was 0.9 (0-9.9), 98.8 (95.9-99.5), and 99.4 (98.8-99.7), respectively, at two weeks after V3. Both parameters were significantly increased from V2 across all groups (p < 0.05). Seroconversion and neutralization positivity rates in PD, HD, and control groups were 100% but were impaired in KT patients (39% and 16%, respectively). S1-specific T-cell counts were increased in PD and HD groups (p < 0.05) but not in KT patients. The positive S1-specific T-cell responder rate was > 90% in PD, HD, and control groups, which was higher than that in KT recipients (74%, p < 0.05). The heterologous inactivated virus/ChAdOx1 nCoV-19 vaccination strategy elicited greater immunogenicity among dialysis patients; however, inadequate responses remained among KT recipients (TCTR20210226002).
Identifiants
pubmed: 35246578
doi: 10.1038/s41598-022-07574-w
pii: 10.1038/s41598-022-07574-w
pmc: PMC8897448
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3587Subventions
Organisme : National Research Council of Thailand
ID : 102912
Organisme : Ramathibodi Foundation, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
ID : 31010055
Informations de copyright
© 2022. The Author(s).
Références
Nat Med. 2021 Nov;27(11):2032-2040
pubmed: 34588689
Clin Kidney J. 2021 Aug 13;14(11):2349-2355
pubmed: 34754430
Infect Dis Ther. 2022 Feb;11(1):351-365
pubmed: 34859359
Clin Microbiol Infect. 2020 Sep;26(9):1256.e9-1256.e11
pubmed: 32531475
Transpl Infect Dis. 2021 Feb;23(1):e13388
pubmed: 32585765
Am J Kidney Dis. 2022 Feb;79(2):185-192.e1
pubmed: 34508833
Nat Rev Nephrol. 2021 Dec;17(12):785-787
pubmed: 34580488
Lancet. 2021 Oct 23;398(10310):1482-1484
pubmed: 34619100
Clin J Am Soc Nephrol. 2007 Mar;2(2):374-84
pubmed: 17699437
Immun Inflamm Dis. 2020 Dec;8(4):534-543
pubmed: 32770646
Front Cell Infect Microbiol. 2021 Sep 10;11:690621
pubmed: 34568087
Am J Transplant. 2022 Feb;22(2):634-639
pubmed: 34551181
N Engl J Med. 2021 Aug 12;385(7):661-662
pubmed: 34161700
Am J Transplant. 2022 Mar;22(3):813-822
pubmed: 34657386
Clin Infect Dis. 2021 Jan 27;72(2):340-350
pubmed: 33501974
Vaccines (Basel). 2021 Oct 04;9(10):
pubmed: 34696238
PLoS One. 2020 Sep 15;15(9):e0239250
pubmed: 32931517
Nat Immunol. 2021 May;22(5):620-626
pubmed: 33674800
Cell. 2021 Apr 29;184(9):2348-2361.e6
pubmed: 33730597
Nephrol Dial Transplant. 2021 Sep 27;36(10):1947-1949
pubmed: 34289075
Asian Pac J Allergy Immunol. 2021 Oct 31;:
pubmed: 34717527
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
Ann Intern Med. 2021 Sep;174(9):1336-1338
pubmed: 34029487
Emerg Infect Dis. 2021 Jan;27(1):
pubmed: 33058753
Lancet. 2021 Dec 19;396(10267):1979-1993
pubmed: 33220855
Transpl Infect Dis. 2021 Dec;23(6):e13740
pubmed: 34606134
Kidney Int. 2021 Nov;100(5):1127-1128
pubmed: 34481804
JAMA. 2021 May 4;325(17):1784-1786
pubmed: 33720292
Kidney Int. 2021 Sep;100(3):702-704
pubmed: 34216675
JAMA. 2021 Jun 1;325(21):2204-2206
pubmed: 33950155
Lancet. 2021 Sep 18;398(10305):1038-1041
pubmed: 34391504