Astodrimer sodium and bacterial vaginosis: a mini review.
Astodrimer sodium
Bacterial vaginosis
Non-antibiotic treatment
Vaginal gel
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
10
11
2021
accepted:
28
01
2022
pubmed:
6
3
2022
medline:
23
7
2022
entrez:
5
3
2022
Statut:
ppublish
Résumé
Bacterial vaginosis (BV) is the most common vaginal infection affecting women of childbearing age, and is associated with a substantial burden on women's physical, emotional, sexual and social lives, as well as being linked to a number of gynaecological and obstetrical complications and adverse pregnancy outcomes. Antibiotics, such as metronidazole or clindamycin, are recommended as first-line treatment for BV, but may be associated with antibiotic resistance, high rates of recurrence and poor patient treatment satisfaction. Astodrimer sodium gel is a novel, non-antibiotic treatment for BV that is not systemically absorbed. It prevents pathogenic bacteria from adhering to the vaginal wall, and disrupts and inhibits the formation of pathogenic bacterial biofilms. Clinical cure rates of 50-57% were observed in patients with BV treated with astodrimer sodium compared with 17-21% treated with placebo (p < 0.001) in Phase 3 trials. In a separate Phase 3 trial, recurrence of BV occurred in 44% of patients treated with astodrimer sodium compared with 54% of patients who received placebo (p = 0.015). Astodrimer sodium is well tolerated, with vulvovaginal candidosis being the only treatment-related adverse event reported to occur more often than with placebo. The availability of astodrimer sodium, a well-tolerated, convenient, non-antibiotic treatment for BV, represents significant progress in the treatment of this burdensome condition.
Identifiants
pubmed: 35246717
doi: 10.1007/s00404-022-06429-z
pii: 10.1007/s00404-022-06429-z
pmc: PMC9300565
doi:
Substances chimiques
Anti-Bacterial Agents
0
Dendrimers
0
Metronidazole
140QMO216E
Polylysine
25104-18-1
Clindamycin
3U02EL437C
astodrimer
F8H3J9KSY9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-108Informations de copyright
© 2022. The Author(s).
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