Experimental Urethral Infection with Neisseria gonorrhoeae.
Journal
Current topics in microbiology and immunology
ISSN: 0070-217X
Titre abrégé: Curr Top Microbiol Immunol
Pays: Germany
ID NLM: 0110513
Informations de publication
Date de publication:
05 Mar 2022
05 Mar 2022
Historique:
entrez:
5
3
2022
pubmed:
6
3
2022
medline:
6
3
2022
Statut:
aheadofprint
Résumé
Gonorrhea rates and antibiotic resistance are both increasing. Neisseria gonorrhoeae (Ng) is an exclusively human pathogen and is exquisitely adapted to its natural host. Ng can subvert immune responses and undergoes frequent antigenic variation, resulting in limited immunity and protection from reinfection. Previous gonococcal vaccine efforts have been largely unsuccessful, and the last vaccine to be tested in humans was more than 35 years ago. Advancing technologies and the threat of untreatable gonorrhea have fueled renewed pursuit of a vaccine as a long-term sustainable solution for gonorrhea control. Despite the development of a female mouse model of genital gonococcal infection two decades ago, correlates of immunity or protection remain largely unknown, making the gonococcus a challenging vaccine target. The controlled human urethral infection model of gonorrhea (Ng CHIM) has been used to study gonococcal pathogenesis and the basis of anti-gonococcal immunity. Over 200 participants have been inoculated without serious adverse events. The Ng CHIM replicates the early natural course of urethral infection. We are now at an inflexion point to pivot the use of the model for vaccine testing to address the urgency of improved gonorrhea control. Herein we discuss the need for gonorrhea vaccines, and the advantages and limitations of the Ng CHIM in accelerating the development of gonorrhea vaccines.
Identifiants
pubmed: 35246736
doi: 10.1007/82_2021_250
pmc: PMC9441470
mid: NIHMS1806974
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : U01 AI114378
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Lancet Infect Dis. 2017 Aug;17(8):e235-e279
pubmed: 28701272
J Infect Dis. 1999 Feb;179(2):371-81
pubmed: 9878021
Annu Rev Microbiol. 2017 Sep 8;71:665-686
pubmed: 28886683
Lancet. 1997 Jun 28;349(9069):1868-73
pubmed: 9217758
Nat Immunol. 2002 Mar;3(3):229-36
pubmed: 11850628
Methods Mol Biol. 2019;1997:413-429
pubmed: 31119637
Am Fam Physician. 2016 Nov 1;94(9):723-726
pubmed: 27929243
J Microbiol Methods. 2011 Dec;87(3):350-4
pubmed: 21986029
Sex Transm Dis. 1992 Jul-Aug;19(4):185-92
pubmed: 1411832
Bull World Health Organ. 2019 Aug 01;97(8):548-562P
pubmed: 31384073
Front Microbiol. 2011 Jul 01;2:107
pubmed: 21747807
Mol Microbiol. 1997 Dec;26(5):971-80
pubmed: 9426134
Euro Surveill. 2019 Mar;24(10):
pubmed: 30862336
Mucosal Immunol. 2014 Jan;7(1):165-76
pubmed: 23757303
Sex Transm Dis. 1994 Mar-Apr;21(2 Suppl):S32-7
pubmed: 8042113
Curr Opin Infect Dis. 2021 Feb 1;34(1):40-49
pubmed: 33337618
Vaccine. 1996 Jul;14(10):1009-15
pubmed: 8873396
Infect Immun. 2006 May;74(5):2965-74
pubmed: 16622235
Semin Pediatr Infect Dis. 2005 Oct;16(4):258-70
pubmed: 16210106
J Infect Dis. 2013 Dec 1;208(11):1821-9
pubmed: 24048962
J Infect Dis. 2012 Jul 1;206(1):6-14
pubmed: 22517910
PLoS Med. 2017 Jul 7;14(7):e1002344
pubmed: 28686231
Clin Infect Dis. 2018 Jan 18;66(3):437-443
pubmed: 29136127
Vaccine. 2007 Apr 20;25(16):3080-4
pubmed: 17287053
Lancet. 1992 Oct 31;340(8827):1074-8
pubmed: 1357461
Clin Infect Dis. 2005 Jul 1;41(1):67-74
pubmed: 15937765
Infect Immun. 1999 Nov;67(11):5699-708
pubmed: 10531218
Front Immunol. 2019 Feb 19;9:3187
pubmed: 30838004
J Clin Invest. 1975 Jun;55(6):1349-56
pubmed: 805797
Lancet. 2017 Sep 30;390(10102):1603-1610
pubmed: 28705462
Sex Health. 2019 Sep;16(5):412-425
pubmed: 31437420
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17142-7
pubmed: 16275906
Mucosal Immunol. 2012 Jan;5(1):19-29
pubmed: 21937985
MMWR Morb Mortal Wkly Rep. 2020 Dec 18;69(50):1911-1916
pubmed: 33332296
Mol Microbiol. 1998 Feb;27(3):611-6
pubmed: 9489672
Sex Transm Dis. 2017 May;44(5):266-271
pubmed: 28407641
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14851-6
pubmed: 8962144
Infect Immun. 2005 Jul;73(7):4171-9
pubmed: 15972507
Vaccines (Basel). 2019 Jan 05;7(1):
pubmed: 30621260
Am J Epidemiol. 1999 Feb 15;149(4):353-8
pubmed: 10025478
Br J Vener Dis. 1946 Jun;22:84
pubmed: 20989324
Clin Infect Dis. 2019 Sep 13;69(7):1101-1111
pubmed: 30551148
Sex Transm Dis. 2001 Oct;28(10):555-64
pubmed: 11689753
Sex Transm Infect. 2013 Dec;89(8):613-5
pubmed: 23920397
Clin Infect Dis. 2015 Jul 15;61(2):260-9
pubmed: 25900168
Sex Transm Dis. 2011 Aug;38(8):750-4
pubmed: 21317686
Sex Transm Infect. 2013 Dec;89(8):672-8
pubmed: 24005255
Vaccine. 1985 Mar;3(1):3-10
pubmed: 2408396
Sex Transm Dis. 2019 Nov;46(11):743-747
pubmed: 31517767
Obstet Gynecol. 2012 Jul;120(1):37-43
pubmed: 22678036
Infect Immun. 2010 Jan;78(1):433-40
pubmed: 19901062
J Lancet. 1946 Mar;66:65-7
pubmed: 21017367
Vaccine. 2004 Jan 26;22(5-6):660-9
pubmed: 14741158
Vaccine. 1991 Mar;9(3):154-62
pubmed: 1675029
Sex Transm Dis. 2020 Dec;47(12):779-789
pubmed: 32773611
Vaccine. 1999 Feb 26;17(7-8):754-64
pubmed: 10067680
EMBO J. 1997 Jun 16;16(12):3435-45
pubmed: 9218786
J Infect Dis. 2000 Sep;182(3):848-55
pubmed: 10950780
N Engl J Med. 1974 Jan 17;290(3):117-23
pubmed: 4202519
J Infect Dis. 1976 Apr;133(4):441-7
pubmed: 816974
Mucosal Immunol. 2017 Nov;10(6):1594-1608
pubmed: 28272393
PLoS Pathog. 2013;9(8):e1003559
pubmed: 24009500
Curr Opin HIV AIDS. 2016 Mar;11(2):156-62
pubmed: 26628324
Infect Immun. 1997 Jun;65(6):2353-61
pubmed: 9169774
Sex Health. 2018 Feb;15(1):1-12
pubmed: 28838352
Epidemiol Infect. 2014 Nov;142(11):2422-32
pubmed: 25267407
J Exp Med. 1986 Nov 1;164(5):1735-48
pubmed: 3095479
Infect Immun. 1982 Jun;36(3):1006-12
pubmed: 6124502
Int Urol Nephrol. 2011 Dec;43(4):969-74
pubmed: 21442395
mBio. 2011 May 24;2(3):e00095-11
pubmed: 21610119
Euro Surveill. 2019 Feb;24(8):
pubmed: 30808445
mBio. 2013 Nov 19;4(6):e00892-13
pubmed: 24255126
Vaccine. 2009 Jun 24;27 Suppl 2:B3-12
pubmed: 19481313
PLoS Pathog. 2020 Dec 8;16(12):e1008602
pubmed: 33290434
Future Microbiol. 2012 Dec;7(12):1401-22
pubmed: 23231489
mBio. 2019 Nov 5;10(6):
pubmed: 31690678
Front Microbiol. 2011 May 31;2:123
pubmed: 21734909
J Exp Med. 1997 May 5;185(9):1557-64
pubmed: 9151893