Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish.
CNS
Microglia
Müller glia
Neurogenesis
Neuroinflammation
Stem cells
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
27
09
2021
accepted:
24
02
2022
pubmed:
6
3
2022
medline:
21
4
2022
entrez:
5
3
2022
Statut:
ppublish
Résumé
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller glia to function as stem cells, producing progenitors that regenerate photoreceptors. MicroRNAs (miRNAs) regulate CNS neurogenesis, but the roles of miRNAs in injury-induced neuronal regeneration are largely unknown. In the embryonic zebrafish retina, miR-18a regulates photoreceptor differentiation. The purpose of the current study was to determine, in zebrafish, the function of miR-18a during injury-induced photoreceptor regeneration. RT-qPCR, in situ hybridization, and immunohistochemistry showed that miR-18a expression increases throughout the retina between 1 and 5 days post-injury (dpi). To test miR-18a function during photoreceptor regeneration, we used homozygous miR-18a mutants (miR-18a
Identifiants
pubmed: 35246819
doi: 10.1007/s12035-022-02783-w
pii: 10.1007/s12035-022-02783-w
pmc: PMC9018604
mid: NIHMS1786718
doi:
Substances chimiques
MicroRNAs
0
Bromodeoxyuridine
G34N38R2N1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2910-2931Subventions
Organisme : NEI NIH HHS
ID : P30EY004068
Pays : United States
Organisme : NEI NIH HHS
ID : R21EY031526
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY013934
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY004068
Pays : United States
Organisme : NEI NIH HHS
ID : 1R15EY031089-01
Pays : United States
Organisme : NEI NIH HHS
ID : R15 EY031089
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY031526
Pays : United States
Organisme : NEI NIH HHS
ID : F30 EY031142
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY007060
Pays : United States
Organisme : NEI NIH HHS
ID : T32EY013934
Pays : United States
Organisme : NEI NIH HHS
ID : P30EYO7003
Pays : United States
Organisme : NEI NIH HHS
ID : R01EY07060
Pays : United States
Organisme : NEI NIH HHS
ID : F30EY031142
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY007003
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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