Different responses to DNA damage determine ageing differences between organs.
DNA damage response
ERCC1
adult stem cells
genome maintenance
liver
nucleotide excision repair
organoids
small intestine
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
17
12
2021
received:
21
07
2021
accepted:
05
01
2022
pubmed:
6
3
2022
medline:
16
4
2022
entrez:
5
3
2022
Statut:
ppublish
Résumé
Organs age differently, causing wide heterogeneity in multimorbidity, but underlying mechanisms are largely elusive. To investigate the basis of organ-specific ageing, we utilized progeroid repair-deficient Ercc1
Identifiants
pubmed: 35246937
doi: 10.1111/acel.13562
pmc: PMC9009128
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13562Subventions
Organisme : NIA NIH HHS
ID : P01 AG017242
Pays : United States
Informations de copyright
© 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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