Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds.
CAM assay
angiogenesis
cotton dressing
tissue engineering
wound healing
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
06
02
2022
received:
18
11
2021
accepted:
17
02
2022
pubmed:
6
3
2022
medline:
6
5
2022
entrez:
5
3
2022
Statut:
ppublish
Résumé
This research on a thyroxine/heparin-based cotton wound dressing tests angiogenic and wound healing ability of thyroxine/heparin in a chick chorionic allantoic membrane bioassay and in skin wounds in healthy rats. Commercially available cotton dressings were simply loaded with thyroxine/heparin solutions and coated with wax. Prior to undertaking the animal study, we assessed in vitro release of thyroxine/heparin from coated and uncoated cotton dressings. Both showed more than 85% release of drug over 14 days, though the lesser release was observed in wax-coated thyroxine/heparin dressing as compared to uncoated thyroxine/heparin dressing. Testing of angiogenesis through CAM assay proved good angiogenic potential of heparin and thyroxin, but the thyroxine found more angiogenic than heparin. In animal study, full-thickness skin wounds of 20 mm diameter showed good healing in both heparin and thyroxine-treated groups. But the most striking result was seen in the thyroxine-treated group where thyroxine showed significant difference with heparin-treated group and completely healed the wounds in 23 days. Thus, the study suggest that thyroxine possesses greater angiogenic and wound healing potential than heparin, and the use of thyroxine/heparin-loaded wax-coated cotton dressing could be a cost-effective option for the management of chronic wounds.
Substances chimiques
Heparin
9005-49-6
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
460-471Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Abdelrahman, T., & Newton, H. (2011). Wound dressings: Principles and practice. Surgery, 29(10), 491-495.
Ahmed, A., Getti, G., & Boateng, J. (2021). Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers. International Journal of Pharmaceutics, 606, 120903.
Ahtzaz, S., Waris, T. S., Shahzadi, L., Chaudhary, A. A., & Rehman, U. I. (2019). Boron for tissue regeneration - It’s loading into chitosan/collagen hydrogels and testing on chorioallantoic membrane to study the effect on angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(8), 525-534.
Albini, A., Benelli, A., Presta, M., Rusnati, M., Ziche, M., Rubartelli, A., Paglialunga, G., Bussolino, A., & Noonan, D. (1996). HIV-tat protein is a heparin-binding angiogenic growth factor. Oncogene, 12(2), 289-297.
Aleem, A. R., Shahzadi, L., Alvi, F., Khan, A. F., Chaudhry, A. A., Rehman, U. I., & Yar, M. (2017). Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. Materials & Design, 133, 416-425.
Aleem, A. R., Shahzadi, L., Tehseen, S., Alvi, F., Chaudhry, A. A., Rehman, U. I., & Yar, M. (2019). Amino acids loaded chitosan/collagen based new membranes stimulate angiogenesis in chorioallantoic membrane assay. International Journal of Biological Macromolecules, 140, 401-406.
Azam, M., Dikici, S., Roman, S., Mehmood, A., Chaudhry, A. A., Rehman, U. I., MacNeil, S., & Yar, M. (2019). Addition of 2-deoxy-d-ribose to clinically used alginate dressings stimulates angiogenesis and accelerates wound healing in diabetic rats. Journal of Biomaterials Applications, 34, 463-475.
Barnea, Y., Amir, A., Leshem, D., Zaretski, A., Weiss, J., Shafir, R., & Gur, E. (2004). Clinical comparative study of aquacel and paraffin gauze dressing for split-skin donor site treatment. Annals of Plastic Surgery, 53(2), 132-136.
Boateng, J., & Catanzano, O. (2015). Advanced therapeutic dressings for effective wound healing-a review. Journal of Pharmaceutical Sciences, 104(11), 3653-3680.
Bridoux, A., Cui, H., Dyskin, E., Schmitzer, A.-R., Yalcin, M., & Mousa, S. A. (2010). Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators. Bioorganic & Medicinal Chemistry Letters, 20(11), 3394-3398.
Briggs, M. (1994). Examining equipment for wound care: The use of forceps and cotton wool in dressing packs. Accident and Emergency Nursing, 2(4), 237-239.
Dabiri, G., Damstetter, E., & Phillips, T. (2016). Choosing a wound dressing based on common wound characteristics. Advances in Wound Care, 5(1), 32-41.
Davis, F. B., Mousa, S. A., O’Connor, L., Mohamed, S., Lin, H.-Y., Cao, H. J., & Davis, P. J. (2004). Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface. Circulation Research, 94(11), 1500-1506.
Dhivya, S., Padma, V. V., & Santhini, E. (2015). Wound dressings - A review. BioMedicine, 5(4), 22.
Folkman, J., Taylor, S., & Spillberg, C. (1983). The role of heparin in angiogenesis. In Ciba found symposium. Wiley Online Library, 100, 132-149.
Hao, W., Han, J., Chu, Y., Huang, L., Zhuang, Y., Sun, J., Li, X., Zhao, Y., Chen, Y., & Dai, J. (2018). Collagen/heparin Bi-affinity multilayer modified collagen scaffolds for controlled bFGF release to improve angiogenesis in vivo. Macromolecular Bioscience, 18(11), 1800086.
Hori, K., Sotozono, C., Hamuro, J., Yamasaki, K., Kimura, Y., Ozeki, M., Tabata, Y., & Kinoshita, S. (2007). Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing. Journal of Controlled Release, 118(2), 169-176.
Hubbell, J. A. (1996). Hydrogel systems for barriers and local drug delivery in the control of wound healing. Journal of Controlled Release, 39(2-3), 305-313.
Ishihara, J., Ishihara, A., Starke, R. D., Peghaire, C. R., Smith, K. E., McKinnon, T. A. J., Tabata, Y., Sasaki, K., White, M. J. V., Fukunaga, K., Laffan, M. A., Lutolf, M. P., Randi, A. M., & Hubbell, J. A. (2019). The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing. Blood, 133(24), 2559-2569.
Johnson, K. E., & Wilgus, T. A. (2014). Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Advances in Wound Care, 3(10), 647-661.
Kanokpanont, S., Damrongsakkul, S., Ratanavaraporn, J., & Aramwit, P. (2013). Physico-chemical properties and efficacy of silk fibroin fabric coated with different waxes as wound dressing. International Journal of Biological Macromolecules, 55, 88-97.
Kirsner, R. S., & Eaglstein, W. H. (1993). The wound healing process. Dermatologic Clinics, 11(4), 629-640.
Liu, X., Zheng, N., Shi, Y.-N., Yuan, J., & Li, L. (2014). Thyroid hormone induced angiogenesis through the integrin αvβ3/protein kinase D/histone deacetylase 5 signaling pathway. Journal of Molecular Endocrinology, 52(3), 245-254.
Lobb, R. R., Alderman, E. M., & Fett, J. W. (1985). Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor. Biochemistry, 24(19), 4969-4973.
Lokman, N. A., Elder, A. S. F., Ricciardelli, C., & Oehler, M. K. (2012). Chick chorioallantoic membrane (CAM) assay as an in vivo model to study the effect of newly identified molecules on ovarian cancer invasion and metastasis. International Journal of Molecular Sciences, 13(8), 9959-9970.
Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1-2), 55-63.
Mousa, S. A., O’Connor, L., Davis, F. B., & Davis, P. J. (2006). Proangiogenesis action of the thyroid hormone analog 3, 5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated. Endocrinology, 147(4), 1602-1607.
Ratner, B. D. (2002). Reducing capsular thickness and enhancing angiogenesis around implant drug release systems. Journal of Controlled Release, 78(1-3), 211-218.
Rodrıguez, M., Vila-Jato, J. L., & Torres, D. (1998). Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. Journal of Controlled Release, 55(1), 67-77.
Satish, A., & Korrapati, P. S. (2015). Fabrication of a triiodothyronine incorporated nanofibrous biomaterial: Its implications on wound healing. RSC Advances, 5(102), 83773-83780.
Sood, A., Granick, M. S., & Tomaselli, N. L. (2014). Wound dressings and comparative effectiveness data. Advances in Wound Care, 3(8), 511-529.
Thomas, S. (2004). 12 wound dressings. The epidermis in wound healing, (p. 215).
Tonnesen, M. G., Feng, X., & Clark, R. A. (2000). Angiogenesis in wound healing. In Journal of investigative dermatology symposium proceedings. Elsevier, 5(1), 40-46.
Velnar, T., Bailey, T., & Smrkolj, V. (2009). The wound healing process: An overview of the cellular and molecular mechanisms. Journal of International Medical Research, 37(5), 1528-1542.
Wong, A. K., Schonmeyer, B. H., Singh, P., Carlson, D. L., Li, S., & Mehrara, B. J. (2008). Histologic analysis of angiogenesis and lymphangiogenesis in acellular human dermis. Plastic and Reconstructive Surgery, 121(4), 1144-1152.
Worley, C. A. (2005). So, what do I put on this wound? Making sense of the wound dressing puzzle: Part II. Dermatology Nursing, 17(3), 204.
Xiao, Y., Riahi, R., Torab, P., Zhang, D. D., & Wong, P. K. (2019). Collective cell migration in 3D epithelial wound healing. ACS Nano, 13(2), 1204-1212.
Yar, M., Gigliobianco, G., Shahzadi, L., Dew, L., Siddiqi, S. A., Khan, A. F., Chaudhry, A. A., Rehman, U. I., & MacNeil, S. (2016). Production of chitosan PVA PCL hydrogels to bind heparin and induce angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 65(9), 466-476.
Zhang, G.-Y., Langan, E. A., Meier, N. T., Funk, W., Siemers, F., & Paus, R. (2019). Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo. PLoS One, 14(3), e0212659.