Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B

Animals Epithelium Humans Mice RNA, Viral Receptor, Bradykinin B2 / genetics SARS-CoV-2 COVID-19 Drug Treatment
ACE2 B2R-antagonist COVID-19 Kinin Kinin-kallikrein-system SARS-CoV-2

Journal

Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370

Informations de publication

Date de publication:
04 2022
Historique:
received: 28 12 2021
accepted: 15 02 2022
revised: 07 02 2022
pubmed: 6 3 2022
medline: 2 4 2022
entrez: 5 3 2022
Statut: ppublish

Résumé

SARS-CoV-2 has evolved to enter the host via the ACE2 receptor which is part of the kinin-kallikrein pathway. This complex pathway is only poorly understood in context of immune regulation but critical to control infection. This study examines SARS-CoV-2-infection and epithelial mechanisms of the kinin-kallikrein-system at the kinin B

Identifiants

DOI: 10.1007/s00109-022-02182-7 PMID: 35247068 PMC: PMC8897552
pubmed: 35247068
doi: 10.1007/s00109-022-02182-7
pii: 10.1007/s00109-022-02182-7
pmc: PMC8897552
doi:

Substances chimiques

RNA, Viral 0
Receptor, Bradykinin B2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

613-627

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 398577603
Organisme : Deutsche Forschungsgemeinschaft
ID : TR22
Organisme : Bundesministerium für Bildung und Forschung
ID : ESACPE
Organisme : Bundesministerium für Bildung und Forschung
ID : 01KI20169A

Informations de copyright

© 2022. The Author(s).

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Auteurs

Constanze A Jakwerth (CA)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.
ORCID: 0000-0002-2902-0393

Martin Feuerherd (M)

Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, German Center of Infectiology Research (DZIF), Munich partner site, Munich, Germany.

Ferdinand M Guerth (FM)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.

Madlen Oelsner (M)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.

Linda Schellhammer (L)

Institute of Laboratory Animal Science, University of Zurich, Zurich, Switzerland.

Johanna Giglberger (J)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.
Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

Lisa Pechtold (L)

Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

Claudia Jerin (C)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.
Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

Luisa Kugler (L)

Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

Carolin Mogler (C)

Institute of Pathology, Technical University Munich, Munich, Germany.

Bernhard Haller (B)

Institute of Medical Informatics, Statistics and Epidemiology, Medical School, Technical University of Munich, Munich, Germany.

Anna Erb (A)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.

Barbara Wollenberg (B)

Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

Christoph D Spinner (CD)

Department of Internal Medicine II, University Hospital Rechts Der Isar, Medical School, Technical University of Munich, Munich, Germany.

Thorsten Buch (T)

Institute of Laboratory Animal Science, University of Zurich, Zurich, Switzerland.

Ulrike Protzer (U)

Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, German Center of Infectiology Research (DZIF), Munich partner site, Munich, Germany.

Carsten B Schmidt-Weber (CB)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany. csweber@tum.de.
ORCID: 0000-0002-3203-8084

Ulrich M Zissler (UM)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.

Adam M Chaker (AM)

Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German, Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), CPC-M, and Member of the Helmholtz I&I Initiative, Biedersteiner Str. 29, 80202, Munich, Germany.
Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Tissus › Épithélium › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur de la bradykinine › Récepteur de la bradykinine de type B2 › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Early reduction of SARS-CoV-2-replication in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Early reduction of SARS-CoV-2-replication in...