Caspase mechanisms in the regulation of inflammation.
Apoptosis
Apoptosome
Caspase
Cell death
Inflammasome
Inflammation necroptosis
Protease
Pyroptosis
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
30
09
2021
revised:
22
02
2022
accepted:
26
02
2022
pubmed:
7
3
2022
medline:
15
12
2022
entrez:
6
3
2022
Statut:
ppublish
Résumé
Regulated cell death is defined as genetically encoded pathways that lead towards the demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory, depending on whether the mechanism of death results in cell rupture or not. Inflammatory cell death can lead towards acute and chronic disease. Therefore, it becomes important to distinguish the mechanisms that result in these different inflammatory cell death outcomes. Apoptosis is a non-inflammatory form of cell death where cells resist rupture. In contrast, pyroptosis and necroptosis are inflammatory forms of cell death principally because of release of pro-inflammatory mediators from cells undergoing lysis. This review focusses on the mechanisms of these different cell death outcomes with specific emphasis on the caspase family of proteolytic enzymes.
Identifiants
pubmed: 35248371
pii: S0098-2997(22)00027-9
doi: 10.1016/j.mam.2022.101085
pii:
doi:
Substances chimiques
Caspases
EC 3.4.22.-
Inflammasomes
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101085Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM099040
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.