Magnetic Resonance Angiography After Flow Diversion: The Use of Complementary Magnetic Resonance Angiography Techniques to Monitor Aneurysm Occlusion and Device and Arterial Branch Patency After Flow Diverter Placement.


Journal

World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275

Informations de publication

Date de publication:
06 2022
Historique:
received: 30 11 2021
revised: 22 02 2022
accepted: 23 02 2022
pubmed: 7 3 2022
medline: 9 6 2022
entrez: 6 3 2022
Statut: ppublish

Résumé

Few studies have evaluated flow diversion with magnetic resonance angiography (MRA). Studies have shown better success of MRA in assessing the aneurysm response, but limited success in assessing stent patency. The patency of arterial branches on MRA remains to be explored. Retrospective evaluation of 31 consecutive cases of carotid aneurysms treated with flow diversion was performed with noncontrast time-of-flight (TOF), contrast-enhanced TOF, and cine MRA (time-resolved angiography with interleaved stochastic trajectories) independently by 2 investigators for aneurysm occlusion, stent patency, and arterial branch patency. Digital subtraction angiography served as the gold standard technique. Patients were 6 men and 25 women with a mean ± SD age of 57.8 ± 12.27 years (range, 32-79 years). Stent patency, aneurysm occlusion, and branch patency mostly revealed substantial to perfect interobserver agreement (κ >0.60). Sensitivity, specificity, positive predictive value, and negative predictive value for stent patency on raw data images of TOF were 0.50, 0.86, 0.20, and 0.96 and on contrast-enhanced TOF were 1.0, 0.93, 0.50, and 1.0. Ranges for aneurysm response on the 3 MRA scans were 0.78-0.89 for sensitivity, 0.54-0.92 for specificity, 0.73-0.93 for positive predictive value, and 0.78-0.86 for negative predictive value. Ranges for arterial branch patency among the 3 MRA scans were 0.87-0.96 for sensitivity, 0.50-1.0 for specificity, 0.90-1.0 for positive predictive value, and 0.33-0.80 for negative predictive value. Aneurysm occlusion, stent patency, and arterial branch patency in flow diversion can be successfully evaluated with the combination of 3 MRA techniques.

Sections du résumé

BACKGROUND
Few studies have evaluated flow diversion with magnetic resonance angiography (MRA). Studies have shown better success of MRA in assessing the aneurysm response, but limited success in assessing stent patency. The patency of arterial branches on MRA remains to be explored.
METHODS
Retrospective evaluation of 31 consecutive cases of carotid aneurysms treated with flow diversion was performed with noncontrast time-of-flight (TOF), contrast-enhanced TOF, and cine MRA (time-resolved angiography with interleaved stochastic trajectories) independently by 2 investigators for aneurysm occlusion, stent patency, and arterial branch patency. Digital subtraction angiography served as the gold standard technique.
RESULTS
Patients were 6 men and 25 women with a mean ± SD age of 57.8 ± 12.27 years (range, 32-79 years). Stent patency, aneurysm occlusion, and branch patency mostly revealed substantial to perfect interobserver agreement (κ >0.60). Sensitivity, specificity, positive predictive value, and negative predictive value for stent patency on raw data images of TOF were 0.50, 0.86, 0.20, and 0.96 and on contrast-enhanced TOF were 1.0, 0.93, 0.50, and 1.0. Ranges for aneurysm response on the 3 MRA scans were 0.78-0.89 for sensitivity, 0.54-0.92 for specificity, 0.73-0.93 for positive predictive value, and 0.78-0.86 for negative predictive value. Ranges for arterial branch patency among the 3 MRA scans were 0.87-0.96 for sensitivity, 0.50-1.0 for specificity, 0.90-1.0 for positive predictive value, and 0.33-0.80 for negative predictive value.
CONCLUSIONS
Aneurysm occlusion, stent patency, and arterial branch patency in flow diversion can be successfully evaluated with the combination of 3 MRA techniques.

Identifiants

pubmed: 35248768
pii: S1878-8750(22)00243-1
doi: 10.1016/j.wneu.2022.02.096
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e147-e155

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Krishnamoorthy Thamburaj (K)

Department of Radiology, Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA. Electronic address: kthamburaj@pennstatehealth.psu.edu.

Samer Zammar (S)

Department of Neurosurgery, Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA.

Annie Tsay (A)

Internal Medicine Cambridge Health Alliance, Cambridge, Massachusetts, USA.

Kyaw Tun (K)

Department of Radiology, Penn State Health Community Practice Division, Harrisburg, Pennsylvania, USA.

Scott Simon (S)

Department of Neurosurgery, Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA.

Paul Kalapos (P)

Department of Radiology, Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA.

Marco Fiorelli (M)

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Kevin Cockroft (K)

Department of Neurosurgery, Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA.

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