Nitrites as precursors of N-nitrosation in pharmaceutical samples - A trace level analysis.
Excipients
Metformin
N-nitrosodimethylamine
Nitrite
Nitrosamines
UPLC-MS
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
10 May 2022
10 May 2022
Historique:
received:
19
11
2021
revised:
01
02
2022
accepted:
15
02
2022
pubmed:
7
3
2022
medline:
6
4
2022
entrez:
6
3
2022
Statut:
ppublish
Résumé
The ultra-performance liquid chromatography (UPLC) method, which involves pre-column derivatization of nitrite with 2,3-diaminonaphthalene (DAN) to form 2,3-naphthotriazole (NAT), offers the advantages of easy sample preparation, simple derivatization, stable derivatives, rapid analysis, high sensitivity and specificity and lack of interferences for determining nitrite in pharmaceutical samples. Determination of NAT was performed on a an Acquity UPLC HSS T3 column using a gradient elution of 0.1% formic acid with acetonitrile at flow rate of 0.4 mL/min and temperature at 45 °C. The single-quadrupole mass detector was operated in the positive ion mode. Quadrupole mass analyser was employed in selected ion monitoring mode using a target ion at m/z = 170 as [M+H]
Identifiants
pubmed: 35248987
pii: S0731-7085(22)00098-X
doi: 10.1016/j.jpba.2022.114677
pii:
doi:
Substances chimiques
Nitrites
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114677Informations de copyright
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