High-content phenotypic screening identifies novel chemistries that disrupt mosquito activity and development.

Aedes Animals Insecticides / chemistry Larva Mosquito Control / methods Mosquito Vectors Phenotype
Active ingredient Aedes aegypti GPCR Insecticide Larvae Mode of action Mosquito Phenotypic screening

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 08 10 2021
revised: 22 12 2021
accepted: 05 01 2022
entrez: 7 3 2022
pubmed: 8 3 2022
medline: 9 3 2022
Statut: ppublish

Résumé

New classes of chemistries are needed to control insecticide resistant populations of mosquitoes and prevent transmission of vector-borne diseases (VBDs). Organismal screens of chemical collections have played an important role in the search for new vector insecticides and the identification of active ingredients (AIs) that cause rapid mortality of mosquitoes. Advances in image-based screening offer an opportunity to identify chemistries that operate via novel biochemical modes and investigate the range of phenotypes exhibited by mosquitoes following exposure to lethal and sub-lethal chemical dose. An automated, high throughput phenotypic screen (HTS) employing high-content imaging of first instar (L1) Aedes aegypti larvae was developed to identify chemistries associated with mortality and atypical morphological phenotypes. A pilot screen of the Library of Pharmacologically Active Compounds (LOPAC

Identifiants

DOI: 10.1016/j.pestbp.2022.105037 PMID: 35249647
pubmed: 35249647
pii: S0048-3575(22)00004-9
doi: 10.1016/j.pestbp.2022.105037
pii:
doi:

Substances chimiques

Insecticides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105037

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

M V Murgia (MV)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

S Sharan (S)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

J Kaur (J)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

W Austin (W)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

L Hagen (L)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

L Wu (L)

Chemical Genomics Facility at Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907-2089, USA.

L Chen (L)

Chemical Genomics Facility at Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907-2089, USA.

J A Scott (JA)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2089, USA.

D P Flaherty (DP)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2089, USA.

M E Scharf (ME)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA.

V J Watts (VJ)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2089, USA.

C A Hill (CA)

Department Entomology, Purdue University, West Lafayette, IN 47907-2089, USA. Electronic address: hillca@purdue.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Aedes › High-content phenotypic screening identifies...
questionsmedicales.fr › Eucaryotes › Animaux › High-content phenotypic screening identifies...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Insecticides › High-content phenotypic screening identifies...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › High-content phenotypic screening identifies...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Contrôle des maladies transmissibles › Lutte contre les nuisibles › Lutte contre les insectes › Lutte contre les moustiques › High-content phenotypic screening identifies...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Chaîne d'infection › Vecteurs de maladies › Vecteurs arthropodes › Vecteurs insectes › Vecteurs moustiques › High-content phenotypic screening identifies...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › High-content phenotypic screening identifies...