Postsynaptic Potential Energy as Determinant of Synaptic Plasticity.
computational model
homeostatic plasticity
homo- and heterosynaptic plasticity
metabolic energy
synaptic plasticity
Journal
Frontiers in computational neuroscience
ISSN: 1662-5188
Titre abrégé: Front Comput Neurosci
Pays: Switzerland
ID NLM: 101477956
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
10
2021
accepted:
13
01
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Metabolic energy can be used as a unifying principle to control neuronal activity. However, whether and how metabolic energy alone can determine the outcome of synaptic plasticity remains unclear. This study proposes a computational model of synaptic plasticity that is completely determined by energy. A simple quantitative relationship between synaptic plasticity and postsynaptic potential energy is established. Synaptic weight is directly proportional to the difference between the baseline potential energy and the suprathreshold potential energy and is constrained by the maximum energy supply. Results show that the energy constraint improves the performance of synaptic plasticity and avoids setting the hard boundary of synaptic weights. With the same set of model parameters, our model can reproduce several classical experiments in homo- and heterosynaptic plasticity. The proposed model can explain the interaction mechanism of Hebbian and homeostatic plasticity at the cellular level. Homeostatic synaptic plasticity at different time scales coexists. Homeostatic plasticity operating on a long time scale is caused by heterosynaptic plasticity and, on the same time scale as Hebbian synaptic plasticity, is caused by the constraint of energy supply.
Identifiants
pubmed: 35250524
doi: 10.3389/fncom.2022.804604
pmc: PMC8891168
doi:
Types de publication
Journal Article
Langues
eng
Pagination
804604Informations de copyright
Copyright © 2022 Chen, Xie, Wang and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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