Functional Genomic Analysis of Amphetamine Sensitivity in
DGRP
Drosophila
S6K (70-kDa ribosomal protein S6 kinase)
amphetamine
dopamine transporter
mammalian target of rapamycin (mTOR)
psychostimulants
transcriptomic (RNA-Seq)
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
12
2021
accepted:
24
01
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Abuse of psychostimulants, including amphetamines (AMPHs), is a major public health problem with profound psychiatric, medical, and psychosocial complications. The actions of these drugs at the dopamine transporter (DAT) play a critical role in their therapeutic efficacy as well as their liability for abuse and dependence. To date, however, the mechanisms that mediate these actions are not well-understood, and therapeutic interventions for AMPH abuse have been limited. Drug exposure can induce broad changes in gene expression that can contribute to neuroplasticity and effect long-lasting changes in neuronal function. Identifying genes and gene pathways perturbed by drug exposure is essential to our understanding of the molecular basis of drug addiction. In this study, we used
Identifiants
pubmed: 35250674
doi: 10.3389/fpsyt.2022.831597
pmc: PMC8894854
doi:
Types de publication
Journal Article
Langues
eng
Pagination
831597Subventions
Organisme : NIDA NIH HHS
ID : R01 DA041510
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA042233
Pays : United States
Informations de copyright
Copyright © 2022 Karam, Williams, Morozova, Yuan, Panarsky, Zhang, Hodgkinson, Goldman, Kalachikov and Javitch.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Genome Biol. 2014;15(12):550
pubmed: 25516281
Neuron. 2009 Jan 15;61(1):10-26
pubmed: 19146809
Handb Exp Pharmacol. 2020;258:265-297
pubmed: 31286212
Curr Drug Targets. 2013 Jun;14(7):768-76
pubmed: 23614675
Open Biol. 2020 Aug;10(8):200114
pubmed: 32810425
Neurochem Int. 2017 May;105:80-90
pubmed: 28122248
Neurobiol Dis. 2019 Jan;121:34-46
pubmed: 30236862
Front Mol Neurosci. 2015 Dec 16;8:75
pubmed: 26733799
Neuron. 2011 Feb 24;69(4):628-49
pubmed: 21338876
Nat Commun. 2016 Feb 16;7:10652
pubmed: 26879809
Genes Brain Behav. 2019 Jul;18(6):e12577
pubmed: 31012252
Int Rev Neurobiol. 2009;85:29-33
pubmed: 19607959
J Psychopharmacol. 2013 Jun;27(6):479-96
pubmed: 23539642
PLoS One. 2019 Jan 16;14(1):e0209331
pubmed: 30650089
Neurosci Biobehav Rev. 2008;32(4):707-59
pubmed: 18207241
Mol Psychiatry. 2013 Jul;18(7):824-33
pubmed: 22710269
Neuropharmacology. 2014 Jan;76 Pt B:276-86
pubmed: 23639436
Neuron. 2012 Apr 26;74(2):277-84
pubmed: 22542182
Nat Rev Genet. 2014 Mar;15(3):205-13
pubmed: 24468696
Elife. 2020 Aug 10;9:
pubmed: 32773037
Antioxidants (Basel). 2021 Mar 04;10(3):
pubmed: 33806320
Transl Psychiatry. 2012 Jul 17;2:e140
pubmed: 22806211
Genetics. 2013 Oct;195(2):433-41
pubmed: 23934892
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:331-339
pubmed: 29574227
J Neurosci. 2005 Aug 10;25(32):7377-84
pubmed: 16093388
Hum Genet. 2012 Jun;131(6):977-1008
pubmed: 22207143
Nature. 2012 Feb 08;482(7384):173-8
pubmed: 22318601
Biochem Biophys Res Commun. 2008 Aug 8;372(4):656-61
pubmed: 18510945
J Neurochem. 2014 Jul;130(2):172-84
pubmed: 24666346
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6019-24
pubmed: 10811906
Arch Toxicol. 2017 Nov;91(11):3663-3676
pubmed: 28527032
J Neurochem. 2005 Sep;94(5):1402-10
pubmed: 15992364
Neurochem Res. 2022 Jan;47(1):177-189
pubmed: 33630236
Genetics. 2018 Mar;208(3):853-874
pubmed: 29487145
Hum Genet. 2012 Jun;131(6):959-75
pubmed: 22350798
Front Mol Neurosci. 2012 Nov 12;5:99
pubmed: 23162427
Neuropsychopharmacology. 2008 Jan;33(1):166-80
pubmed: 17805308
Genesis. 2004 Aug;39(4):240-5
pubmed: 15286996
Front Pharmacol. 2012 Feb 06;3:13
pubmed: 22347189
Dis Mon. 2012 Feb;58(2):38-89
pubmed: 22251899
Neuroscience. 2011 Jan 13;172:104-9
pubmed: 20977929
Addict Biol. 2012 Mar;17(2):248-58
pubmed: 21392180
Drug Alcohol Depend. 1986 Feb;16(4):341-60
pubmed: 3698813
CNS Drugs. 2013 Jul;27(7):531-43
pubmed: 23757186
Chromosoma. 2014 Dec;123(6):515-27
pubmed: 24913828
Drug Alcohol Depend. 1983 Apr;11(2):147-65
pubmed: 6134605
Addict Behav. 1993 Jul-Aug;18(4):445-53
pubmed: 8213299
Curr Top Behav Neurosci. 2012;12:537-77
pubmed: 22261702
Prog Neurobiol. 2005 Apr;75(6):406-33
pubmed: 15955613
Neuropsychopharmacology. 2008 Jan;33(1):3-17
pubmed: 17728700
Mamm Genome. 2018 Feb;29(1-2):5-23
pubmed: 29058036
Exp Clin Psychopharmacol. 2003 Feb;11(1):91-101
pubmed: 12622347
Adv Pharmacol. 2018;82:205-234
pubmed: 29413521
PLoS One. 2012;7(8):e42878
pubmed: 22916173
PLoS Biol. 2007 Oct 16;5(10):e274
pubmed: 17941718
Mamm Genome. 2005 May;16(5):291-305
pubmed: 16104378
Genes Brain Behav. 2005 Mar;4(2):110-25
pubmed: 15720407
Mol Neurobiol. 2016 Aug;53(6):3771-3782
pubmed: 26143260
J Neurosci. 2002 Oct 15;22(20):8951-60
pubmed: 12388602
Mol Cell Biol. 2003 Dec;23(24):9117-26
pubmed: 14645523
PLoS One. 2014 Sep 02;9(9):e106035
pubmed: 25181461
Diabetologia. 2011 Apr;54(4):935-44
pubmed: 21190014
Genesis. 2002 Sep-Oct;34(1-2):1-15
pubmed: 12324939
J Neurosci. 2010 Sep 22;30(38):12632-41
pubmed: 20861369
Neuropsychopharmacology. 2018 Apr;43(5):1066-1077
pubmed: 29039413
Mol Psychiatry. 2021 Feb;26(2):370-382
pubmed: 33414501
J Neurobiol. 2003 Mar;54(4):618-27
pubmed: 12555273
Dev Biol. 2010 Aug 1;344(1):150-7
pubmed: 20457147
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18
pubmed: 19339977
J Psychopharmacol. 2020 Nov;34(11):1176-1199
pubmed: 32854585
Nat Neurosci. 2013 Nov;16(11):1537-43
pubmed: 24165680
J Neurosci. 2011 Nov 9;31(45):16086-93
pubmed: 22072660