Brainstem Associated Somatosensory Evoked Potentials and Response to Vagus Nerve Stimulation: An Investigation of the Vagus Afferent Network.

epilepsy outcomes somatosensory evoked potentials vagus afferent network vagus nerve stimulation

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2021
Historique:
received: 31 08 2021
accepted: 22 12 2021
entrez: 7 3 2022
pubmed: 8 3 2022
medline: 8 3 2022
Statut: epublish

Résumé

Despite decades of clinical usage, selection of patients with drug resistant epilepsy who are most likely to benefit from vagus nerve stimulation (VNS) remains a challenge. The mechanism of action of VNS is dependent upon afferent brainstem circuitry, which comprises a critical component of the Vagus Afferent Network (VagAN). To evaluate the association between brainstem afferent circuitry and seizure response, we retrospectively collected intraoperative data from sub-cortical recordings of somatosensory evoked potentials (SSEP) in 7 children with focal drug resistant epilepsy who had failed epilepsy surgery and subsequently underwent VNS. Using multivariate linear regression, we demonstrate a robust negative association between SSEP amplitude (

Identifiants

DOI: 10.3389/fneur.2021.768539 PMID: 35250790 PMC: PMC8895499
pubmed: 35250790
doi: 10.3389/fneur.2021.768539
pmc: PMC8895499
doi:

Types de publication

Journal Article

Langues

eng

Pagination

768539

Informations de copyright

Copyright © 2022 Suresh, Mithani, Brar, Yan, Strantzas, Vandenberk, Sharma, Yau, Go, Pang, Kerr, Ochi, Otsubo, Jain, Donner, Snead and Ibrahim.

Déclaration de conflit d'intérêts

Unrelated to this study author GI received funds from LivaNova Inc. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Hrishikesh Suresh (H)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Karim Mithani (K)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Karanbir Brar (K)

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Han Yan (H)

Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Samuel Strantzas (S)

Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Mike Vandenberk (M)

Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Roy Sharma (R)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Ivanna Yau (I)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Christina Go (C)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Elizabeth Pang (E)

Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Elizabeth Kerr (E)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Psychology, The Hospital for Sick Children, Toronto, ON, Canada.

Ayako Ochi (A)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Hiroshi Otsubo (H)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Puneet Jain (P)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Elizabeth Donner (E)

Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

O Carter Snead (OC)

Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

George M Ibrahim (GM)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Classifications MeSH