APOE-ε4 Is Associated With Reduced Verbal Memory Performance and Higher Emotional, Cognitive, and Everyday Executive Function Symptoms Two Months After Mild Traumatic Brain Injury.
APOE
affective symptoms
learning
memory
mild traumatic brain injury
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
07
2021
accepted:
21
01
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Substantial variance exists in outcomes after mild traumatic brain injury (MTBI), and these differences are not fully explained by injury characteristics or severity. Genetic factors are likely to play a role in this variance. The aim of this study was to examine associations between the apolipoprotein (APOE)-ε4 allele and memory measures at two months post-MTBI and to evaluate whether subjective cognitive and affective symptoms were associated with APOE-ε4 status. Based on previous research, it was hypothesized that APOE-ε4 carriers would show poorer verbal memory performance compared to APOE-ε4 non-carriers. Neuropsychological data at two months post-injury and blood samples that could be used to assess The APOE-ε4 + status was associated with decreased immediate memory recall ( The APOE-ε4+ allele has a negative effect on verbal memory and symptom burden two months after MTBI.
Sections du résumé
BACKGROUND
BACKGROUND
Substantial variance exists in outcomes after mild traumatic brain injury (MTBI), and these differences are not fully explained by injury characteristics or severity. Genetic factors are likely to play a role in this variance.
OBJECTIVES
OBJECTIVE
The aim of this study was to examine associations between the apolipoprotein (APOE)-ε4 allele and memory measures at two months post-MTBI and to evaluate whether subjective cognitive and affective symptoms were associated with APOE-ε4 status. Based on previous research, it was hypothesized that APOE-ε4 carriers would show poorer verbal memory performance compared to APOE-ε4 non-carriers.
METHODS
METHODS
Neuropsychological data at two months post-injury and blood samples that could be used to assess
RESULTS
RESULTS
The APOE-ε4 + status was associated with decreased immediate memory recall (
CONCLUSION
CONCLUSIONS
The APOE-ε4+ allele has a negative effect on verbal memory and symptom burden two months after MTBI.
Identifiants
pubmed: 35250800
doi: 10.3389/fneur.2022.735206
pmc: PMC8888909
doi:
Types de publication
Journal Article
Langues
eng
Pagination
735206Informations de copyright
Copyright © 2022 Hellstrøm, Andelic, Holthe, Helseth, Server, Eiklid and Sigurdardottir.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurotrauma. 2013 Apr 15;30(8):642-52
pubmed: 23046394
Brain Behav. 2017 Aug 09;7(9):e00791
pubmed: 28948085
Brain Inj. 2011;25(6):596-603
pubmed: 21534737
Lancet. 1974 Jul 13;2(7872):81-4
pubmed: 4136544
J Neurotrauma. 1998 Aug;15(8):573-85
pubmed: 9726257
J Head Trauma Rehabil. 2019 Sep/Oct;34(5):E45-E56
pubmed: 30829814
Neurology. 2002 Apr 9;58(7):1038-44
pubmed: 11940689
Brain Inj. 2007 Sep;21(10):1049-54
pubmed: 17891567
J Int Neuropsychol Soc. 2014 Apr;20(4):444-54
pubmed: 24670469
J Int Neuropsychol Soc. 2021 Apr;27(4):315-328
pubmed: 33138883
J Neurotrauma. 2008 Apr;25(4):279-90
pubmed: 18373478
J Neurotrauma. 2011 Sep;28(9):1683-92
pubmed: 21651315
Psychiatry Res. 2010 Oct 30;179(3):342-9
pubmed: 20483471
Genet Test Mol Biomarkers. 2014 Mar;18(3):202-10
pubmed: 24475734
Arch Clin Neuropsychol. 2006 Aug;21(5):413-20
pubmed: 16843636
J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1191-3
pubmed: 16614010
J Head Trauma Rehabil. 2000 Jun;15(3):869-74
pubmed: 10785619
Ann N Y Acad Sci. 1996 Jan 17;777:139-45
pubmed: 8624076
Neurol India. 2010 Mar-Apr;58(2):264-9
pubmed: 20508347
Nature. 2017 Sep 28;549(7673):523-527
pubmed: 28959956
J Neurotrauma. 2015 Oct 1;32(19):1488-96
pubmed: 25970233
J Neurotrauma. 2017 Jan 15;34(2):380-384
pubmed: 27245878
J Affect Disord. 2009 Apr;114(1-3):94-102
pubmed: 18656266
J Clin Exp Neuropsychol. 2018 Dec;40(10):1050-1061
pubmed: 30124361
Medicina (Kaunas). 2021 Feb 01;57(2):
pubmed: 33535407
Neurosci Biobehav Rev. 2015 Feb;49:8-18
pubmed: 25434880
J Neurol. 1995 Sep;242(9):587-92
pubmed: 8551320
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
J Int Neuropsychol Soc. 2016 Jan;22(1):89-94
pubmed: 26483005
NeuroRehabilitation. 2013;32(4):803-15
pubmed: 23867406
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):363-6
pubmed: 16484645
J Neurosurg. 2002 Jan;96(1):90-6
pubmed: 11795256
Acta Anaesthesiol Scand. 2008 Nov;52(10):1364-9
pubmed: 19025529
Neurology. 2004 Jun 8;62(11):1963-6
pubmed: 15184597
Hum Biol. 2002 Feb;74(1):137-42
pubmed: 11931575
Arch Clin Neuropsychol. 2018 Feb 1;33(1):36-46
pubmed: 28541413
Neuroimage Clin. 2014 Jan 04;4:283-94
pubmed: 25061565
Neuropsychology. 2016 Oct;30(7):775-90
pubmed: 26986748
J Neurotrauma. 2021 Apr 15;38(8):1124-1136
pubmed: 30848161
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
J Int Neuropsychol Soc. 2012 May;18(3):576-84
pubmed: 22390876
Brain Inj. 2010;24(6):886-92
pubmed: 20377344
J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):229-33
pubmed: 15654038
Genomics Inform. 2012 Jun;10(2):117-22
pubmed: 23105939
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5644-51
pubmed: 16567625
Brain Imaging Behav. 2012 Jun;6(2):108-36
pubmed: 22434552
Neurology. 2007 Feb 20;68(8):619-20
pubmed: 17310037
Neurobiol Aging. 2000 Mar-Apr;21(2):245-55
pubmed: 10867209
Brain Inj. 2015;29(9):1018-31
pubmed: 25915580
J Int Neuropsychol Soc. 2000 Jul;6(5):568-79
pubmed: 10932476
J Int Neuropsychol Soc. 2005 May;11(3):215-27
pubmed: 15892898
Ann Neurol. 2002 Jan;51(1):113-7
pubmed: 11782990