Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.
Animals
COVID-19
/ virology
Disease Models, Animal
Down-Regulation
/ drug effects
Humans
Inflammation
/ drug therapy
Lung
/ virology
Membrane Microdomains
/ drug effects
Mice
Mice, Transgenic
SARS-CoV-2
/ pathogenicity
Simvastatin
/ pharmacology
Virus Replication
/ drug effects
COVID-19 Drug Treatment
COVID-19
SARS-CoV-2
inflammation
lipid rafts
statin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
11
2021
accepted:
25
01
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
12
3
2022
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical studies, statins have been identified as beneficial to hospitalized patients with COVID-19. However, experimental evidence of underlying statins protection against SARS-CoV-2 remains elusive. Here we reported for the first-time experimental evidence of the protective effects of simvastatin treatment both
Identifiants
pubmed: 35251001
doi: 10.3389/fimmu.2022.820131
pmc: PMC8895251
doi:
Substances chimiques
Simvastatin
AGG2FN16EV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
820131Informations de copyright
Copyright © 2022 Teixeira, Temerozo, Pereira-Dutra, Ferreira, Mattos, Gonçalves, Sacramento, Palhinha, Cunha-Fernandes, Dias, Soares, Barreto, Cesar-Silva, Fintelman-Rodrigues, Pão, de Freitas, Reis, Hottz, Bozza, Bou-Habib, Saraiva, de Almeida, Viola, Souza and Bozza.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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