Meiotic Genes and DNA Double Strand Break Repair in Cancer.
DNA repair
genomic instability
homologous recombination
meiosis
meiotic genes
mitosis
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
12
2021
accepted:
02
02
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain genomic integrity. In recent years, it has become clear that tumors frequently reactivate genes whose expression is typically restricted to germ cells. As germ cells have specialized pathways to facilitate the exchange of genetic information between homologous chromosomes, their aberrant regulation influences how cancer cells repair DNA double strand breaks (DSB). This drives genomic instability and affects the response of tumor cells to anticancer therapies. Since meiotic genes are usually transcriptionally repressed in somatic cells of healthy tissues, targeting aberrantly expressed meiotic genes may provide a unique opportunity to specifically kill cancer cells whilst sparing the non-transformed somatic cells. In this review, we highlight meiotic genes that have been reported to affect DSB repair in cancers derived from somatic cells. A better understanding of their mechanistic role in the context of homology-directed DNA repair in somatic cancers may provide useful insights to find novel vulnerabilities that can be targeted.
Identifiants
pubmed: 35251135
doi: 10.3389/fgene.2022.831620
pii: 831620
pmc: PMC8895043
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
831620Informations de copyright
Copyright © 2022 Lingg, Rottenberg and Francica.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS Biol. 2011 Oct;9(10):e1001176
pubmed: 22028627
Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):195-212
pubmed: 27098756
Cell. 2001 Jul 13;106(1):59-70
pubmed: 11461702
PLoS Genet. 2020 Sep 15;16(9):e1009048
pubmed: 32931493
Genes Dev. 2018 May 1;32(9-10):620-638
pubmed: 29802124
Science. 2010 Feb 12;327(5967):835
pubmed: 20044538
Curr Biol. 2004 Jan 20;14(2):R56-8
pubmed: 14738748
Nat Cell Biol. 2011 May;13(5):599-610
pubmed: 21478856
Int J Mol Sci. 2016 Jun 06;17(6):
pubmed: 27275820
Genetics. 1992 Oct;132(2):387-402
pubmed: 1427035
Sci Rep. 2018 Oct 17;8(1):15304
pubmed: 30333500
Int J Cancer. 2011 May 1;128(9):2063-74
pubmed: 20635389
Br J Cancer. 1996 Dec;74(12):1984-9
pubmed: 8980401
Cancer Res. 2017 Nov 1;77(21):5712-5716
pubmed: 29061671
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15706-11
pubmed: 14668445
Cancer Immunol Immunother. 2002 Dec;51(11-12):655-62
pubmed: 12439611
Annu Rev Cell Dev Biol. 2004;20:525-58
pubmed: 15473851
Oncol Lett. 2019 Jul;18(1):169-180
pubmed: 31289486
Cell Biol Int. 2000;24(9):621-33
pubmed: 10964452
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Biol Reprod. 2018 Jul 1;99(1):112-126
pubmed: 29385397
Cancer Immun. 2008 Apr 22;8:7
pubmed: 18426187
Science. 2011 Aug 26;333(6046):1157-60
pubmed: 21798893
Nature. 2012 May 13;485(7400):642-5
pubmed: 22660327
Cancer Biol Med. 2021 Feb 15;18(1):74-87
pubmed: 33628586
Nat Rev Mol Cell Biol. 2004 Dec;5(12):983-97
pubmed: 15573136
PLoS Genet. 2016 Jun 30;12(6):e1006146
pubmed: 27362481
Cancer Res. 2007 Dec 15;67(24):11565-75
pubmed: 18089785
PLoS One. 2014 Jun 06;9(6):e98712
pubmed: 24905095
Br J Cancer. 2001 Sep 1;85(5):713-20
pubmed: 11531257
Oncogene. 2017 Jan 12;36(2):182-193
pubmed: 27212034
Nat Commun. 2013;4:2788
pubmed: 24240703
Oncotarget. 2018 Jul 10;9(53):30115-30127
pubmed: 30046392
Cell Cycle. 2020 Apr;19(8):837-854
pubmed: 32223693
Cold Spring Harb Perspect Biol. 2014 Sep 02;6(9):a023192
pubmed: 25183833
Cancer Res. 2009 Mar 15;69(6):2296-304
pubmed: 19258501
Dev Cell. 2005 Jun;8(6):949-61
pubmed: 15935783
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3443-8
pubmed: 18299561
Nat Rev Cancer. 2014 Jun;14(6):389-93
pubmed: 24854081
Int J Cancer. 2004 Apr 20;109(4):568-75
pubmed: 14991579
Nat Commun. 2019 Dec 17;10(1):5759
pubmed: 31848333
Genes Cancer. 2013 Jan;4(1-2):15-25
pubmed: 23946868
Genes Dev. 2007 Jul 15;21(14):1758-66
pubmed: 17639081
J Biol Chem. 2005 Dec 16;280(50):41380-6
pubmed: 16236716
Genes Cells. 2019 Jan;24(1):6-30
pubmed: 30479058
Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8
pubmed: 20177397
Oncotarget. 2018 Dec 28;9(102):37647-37661
pubmed: 30701021
Methods Mol Biol. 2014;1170:29-40
pubmed: 24906307
Cancer Biol Ther. 2006 Sep;5(9):1218-25
pubmed: 16929165
Nat Commun. 2016 Jan 27;7:10499
pubmed: 26813108
Nat Rev Genet. 2013 Nov;14(11):794-806
pubmed: 24136506
Cancer Lett. 2013 Apr 28;330(2):123-9
pubmed: 22776561
Genes Dev. 2005 Jun 1;19(11):1376-89
pubmed: 15937223
Exp Cell Res. 2009 Sep 10;315(15):2593-603
pubmed: 19463812
Cell Rep. 2020 Aug 25;32(8):108068
pubmed: 32846126
Biophys J. 2010 Dec 1;99(11):3763-72
pubmed: 21112301
Clin Cancer Res. 2014 Jul 15;20(14):3799-808
pubmed: 24850846
EMBO Rep. 2011 Dec 23;13(1):44-51
pubmed: 22116401
Nature. 2011 Oct 16;479(7372):241-4
pubmed: 22002605
Cell. 2015 Jul 16;162(2):271-286
pubmed: 26186187
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6
pubmed: 17626182
Cancer Lett. 2001 Mar 26;164(2):189-95
pubmed: 11179834
Nature. 2005 Aug 18;436(7053):1053-7
pubmed: 16107854
Genes (Basel). 2019 Jan 25;10(2):
pubmed: 30691027
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8703-8
pubmed: 9671742
Front Genet. 2018 Nov 05;9:521
pubmed: 30467513
Genes Cancer. 2017 Nov;8(11-12):784-798
pubmed: 29321820
Genes Dev. 2015 Jan 15;29(2):109-22
pubmed: 25593304
J Mol Cell Biol. 2011 Feb;3(1):1-3
pubmed: 21278445
PLoS Genet. 2009 Oct;5(10):e1000702
pubmed: 19851446
J Cell Mol Med. 2018 Oct;22(10):4640-4652
pubmed: 30039914
Dev Cell. 2021 Nov 22;56(22):3100-3114.e4
pubmed: 34758289
Genes Dev. 2010 Jun 15;24(12):1266-80
pubmed: 20551173
Cell. 1997 Feb 7;88(3):375-84
pubmed: 9039264
Am J Pathol. 2016 May;186(5):1340-50
pubmed: 27001628
Nat Struct Mol Biol. 2011 Jan;18(1):56-60
pubmed: 21151113
PLoS One. 2013 Oct 30;8(10):e76251
pubmed: 24204606
Mol Cell Biol. 2002 May;22(9):3078-88
pubmed: 11940665
Nature. 2017 Mar 2;543(7643):126-130
pubmed: 28199302
Development. 2004 Jan;131(1):131-42
pubmed: 14660434
Cancer Manag Res. 2018 Dec 21;11:179-190
pubmed: 30613165
Genes Chromosomes Cancer. 2005 May;43(1):104-12
pubmed: 15672408
Clin Cancer Res. 2003 Jan;9(1):167-73
pubmed: 12538465
Cancer Res. 2002 Nov 15;62(22):6750-5
pubmed: 12438276
Mol Hum Reprod. 2012 Dec;18(12):599-604
pubmed: 22893617
J Transl Med. 2017 Jun 17;15(1):138
pubmed: 28623914
Cell Death Dis. 2020 Jul 9;11(7):519
pubmed: 32647118
Oncotarget. 2015 Jun 30;6(18):15772-87
pubmed: 26158218
J Cell Sci. 2008 Jan;121 Suppl 1:1-84
pubmed: 18089652
J Cell Biol. 1998 Jul 27;142(2):331-9
pubmed: 9679134
Cancer Immunol Res. 2014 Apr;2(4):371-9
pubmed: 24764584
Andrology. 2019 Jul;7(4):415-427
pubmed: 31102330
Sci Rep. 2021 May 3;11(1):9430
pubmed: 33941804
Genes Dev. 2020 Dec 1;34(23-24):1562-1564
pubmed: 33262143
Cell. 2000 Jan 7;100(1):71-8
pubmed: 10647932
EMBO J. 1998 Sep 15;17(18):5497-508
pubmed: 9736627
Cancer Sci. 2021 Mar;112(3):989-996
pubmed: 33382503
Am J Hematol. 2011 Nov;86(11):918-22
pubmed: 21898529
Oncogene. 2006 Apr 20;25(17):2546-57
pubmed: 16331256
Nature. 2004 May 27;429(6990):433-7
pubmed: 15164066
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10572-7
pubmed: 15249670
Cancer Commun (Lond). 2021 Jun;41(6):492-510
pubmed: 33734616
Hum Pathol. 2013 Apr;44(4):472-9
pubmed: 23069255
Cell Death Dis. 2015 Apr 23;6:e1732
pubmed: 25906155
J Cell Biol. 2006 May 22;173(4):497-507
pubmed: 16717126
J Biol Chem. 2018 Jul 6;293(27):10524-10535
pubmed: 29599286
BMC Cancer. 2006 Jan 09;6:6
pubmed: 16401344
Cancer Immun. 2005 Jul 07;5:9
pubmed: 15999985
Genome Dyn. 2009;5:69-80
pubmed: 18948708
Cell. 2003 Feb 21;112(4):423-40
pubmed: 12600308
Br J Cancer. 1999 Dec;81(7):1162-4
pubmed: 10584877
Cancer Discov. 2015 May;5(5):488-505
pubmed: 25770156
Oncol Rep. 2018 Apr;39(4):1583-1590
pubmed: 29393474
Life Sci Alliance. 2018 Dec 10;1(6):e201800259
pubmed: 30569039
Biochem Pharmacol. 2018 Jul;153:217-229
pubmed: 29371029
PLoS Genet. 2010 Nov 04;6(11):e1001190
pubmed: 21079677
Genome Res. 2013 Mar;23(3):419-30
pubmed: 23222848
DNA Repair (Amst). 2006 Apr 8;5(4):455-64
pubmed: 16442857
Cancer Res. 2018 Nov 1;78(21):6196-6208
pubmed: 30185546
Genes Cancer. 2013 Jan;4(1-2):26-38
pubmed: 23946869
Nature. 2006 Jul 6;442(7098):45-50
pubmed: 16823445
Leuk Res. 2003 Jul;27(7):655-60
pubmed: 12681366
Methods Mol Biol. 2014;1170:229-66
pubmed: 24906316
Mol Reprod Dev. 1994 Jun;38(2):231-7
pubmed: 8080653
Genes Dev. 2020 Dec 1;34(23-24):1605-1618
pubmed: 33184224
Nat Genet. 2005 Jan;37(1):41-7
pubmed: 15580272
J Pathol. 2012 Jan;226(2):352-64
pubmed: 21990031
Biol Reprod. 2013 Aug;89(2):29
pubmed: 23759310
Sci Rep. 2017 Apr 6;7(1):681
pubmed: 28386063
Genome Res. 2018 Nov;28(11):1611-1620
pubmed: 30341163
Nat Cell Biol. 2016 Nov;18(11):1208-1220
pubmed: 27723721
Genome Dyn Stab. 2008 Jan 1;2:81-123
pubmed: 21927624
Nat Genet. 2010 Oct;42(10):859-63
pubmed: 20818382
Cold Spring Harb Perspect Biol. 2015 Jan 20;7(5):
pubmed: 25605710
Cell. 2014 Sep 25;159(1):108-121
pubmed: 25259924
Genes Dev. 2012 May 1;26(9):958-73
pubmed: 22549958
Trends Mol Med. 2009 Mar;15(3):120-8
pubmed: 19246245
Clin Cancer Res. 2000 Oct;6(10):3916-22
pubmed: 11051238
Nucleic Acids Res. 2015 Apr 30;43(8):4055-66
pubmed: 25820426
Cancer Detect Prev. 2007;31(4):296-302
pubmed: 17920210
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5211-6
pubmed: 9560255
Cell Res. 2008 Jan;18(1):99-113
pubmed: 18166982
Cell. 1998 Aug 7;94(3):375-86
pubmed: 9708739
Mol Cell Biol. 1999 Nov;19(11):7327-35
pubmed: 10523621
Genes Dev. 2008 Nov 15;22(22):3089-114
pubmed: 19056890
Nat Rev Mol Cell Biol. 2019 Nov;20(11):698-714
pubmed: 31263220
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9947-52
pubmed: 22665764
Genome Biol. 2018 Jul 30;19(1):101
pubmed: 30060743
Cancer Res. 1994 Aug 15;54(16):4257-60
pubmed: 8044767