High iron-mediated increased oral fungal burden, oral-to-gut transmission, and changes to pathogenicity of
3-glucan
Candida albicans
antifungal-resistance
cell wall
iron
oropharyngeal candidiasis
phagocytosis
β-1
Journal
Journal of oral microbiology
ISSN: 2000-2297
Titre abrégé: J Oral Microbiol
Pays: United States
ID NLM: 101551049
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Iron affects the diversity of the oral microbial landscape. Laboratory-strain CAI4 of To understand the effect of iron on the CAI4-strain, wild type (WT) SC5314-strain, and oral isolates of An immunosuppressed murine model of OPC was used to assess the effect of iron on oral-to-gut infection and antifungal susceptibility of the CAI4-strain. High iron enhanced oral and gut fungal levels for the CAI4-strain in mice; CAI4 cells from low iron mice were more susceptible to antifungals. The SC5314-strain and oral isolates showed enhanced antifungal-resistance towards most antifungals tested, under high iron. Iron-mediated cell wall changes and phagocytic response in the SC5315-strain were similar to CAI4; oral isolates showed a variable response. Host iron can potentially alter infection severity and dissemination, efficacy of antifungal treatment, and host immune response during OPC. Clinical isolates showed most of these effects of iron, despite exhibiting a varied cell wall composition-change response to iron.
Sections du résumé
BACKGROUND
BACKGROUND
Iron affects the diversity of the oral microbial landscape. Laboratory-strain CAI4 of
AIM
OBJECTIVE
To understand the effect of iron on the CAI4-strain, wild type (WT) SC5314-strain, and oral isolates of
METHODS
METHODS
An immunosuppressed murine model of OPC was used to assess the effect of iron on oral-to-gut infection and antifungal susceptibility of the CAI4-strain.
RESULTS
RESULTS
High iron enhanced oral and gut fungal levels for the CAI4-strain in mice; CAI4 cells from low iron mice were more susceptible to antifungals. The SC5314-strain and oral isolates showed enhanced antifungal-resistance towards most antifungals tested, under high iron. Iron-mediated cell wall changes and phagocytic response in the SC5315-strain were similar to CAI4; oral isolates showed a variable response.
CONCLUSION
CONCLUSIONS
Host iron can potentially alter infection severity and dissemination, efficacy of antifungal treatment, and host immune response during OPC. Clinical isolates showed most of these effects of iron, despite exhibiting a varied cell wall composition-change response to iron.
Identifiants
pubmed: 35251523
doi: 10.1080/20002297.2022.2044110
pii: 2044110
pmc: PMC8896197
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2044110Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE030130
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE026451
Pays : United States
Informations de copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
Références
J Fungi (Basel). 2017 Sep 23;3(4):
pubmed: 29371567
Eukaryot Cell. 2006 Feb;5(2):347-58
pubmed: 16467475
PLoS Pathog. 2017 Jun 15;13(6):e1006407
pubmed: 28617874
PLoS One. 2015 Jul 21;10(7):e0133476
pubmed: 26197240
Microb Biotechnol. 2009 May;2(3):308-20
pubmed: 21261926
mBio. 2014 Apr 15;5(2):e00911
pubmed: 24736223
Scand J Infect Dis. 2008;40(2):145-53
pubmed: 17852926
J Oral Microbiol. 2019 Mar 18;11(1):1586422
pubmed: 30911359
Antimicrob Agents Chemother. 2014;58(2):756-66
pubmed: 24247141
Front Microbiol. 2017 Nov 14;8:2238
pubmed: 29184547
J Biol Chem. 2020 Jul 17;295(29):10032-10044
pubmed: 32503842
mSphere. 2020 Apr 8;5(2):
pubmed: 32269156
PLoS Pathog. 2016 May 25;12(5):e1005644
pubmed: 27223610
Med Clin North Am. 1992 Jan;76(1):45-62
pubmed: 1727541
PLoS Genet. 2019 Jan 31;15(1):e1007892
pubmed: 30703081
Metallomics. 2019 Dec 11;11(12):2020-2032
pubmed: 31709426
Front Cell Infect Microbiol. 2018 Jun 05;8:185
pubmed: 29922600
Front Microbiol. 2020 Jan 09;10:2993
pubmed: 31993032
Front Microbiol. 2012 Mar 16;3:96
pubmed: 22438853
BMC Oral Health. 2019 Nov 21;19(1):255
pubmed: 31752810
Mol Microbiol. 2014 Jul;93(2):291-305
pubmed: 24889932
Yeast. 2004 Apr 15;21(5):413-27
pubmed: 15116342
Cell Microbiol. 2012 Sep;14(9):1319-35
pubmed: 22587014
Eukaryot Cell. 2015 Dec;14(12):1165-72
pubmed: 26453650
Gut Microbes. 2015;6(5):334-9
pubmed: 26440374
Med Mycol. 2007 Mar;45(2):143-8
pubmed: 17365650
mBio. 2018 Apr 24;9(2):
pubmed: 29691333
J Antimicrob Chemother. 2010 Feb;65(2):289-92
pubmed: 19942619
FEMS Microbiol Rev. 2014 Nov;38(6):1202-34
pubmed: 25205464
J Hosp Infect. 2009 May;72(1):9-16
pubmed: 19303662
Appl Environ Microbiol. 2011 Sep;77(18):6636-43
pubmed: 21764946
J Fungi (Basel). 2020 Jan 16;6(1):
pubmed: 31963180
Microbiol Mol Biol Rev. 1998 Mar;62(1):130-80
pubmed: 9529890
Value Health. 2002 Jan-Feb;5(1):26-34
pubmed: 11873380
Nat Commun. 2019 Nov 22;10(1):5315
pubmed: 31757950
Infect Immun. 2010 Nov;78(11):4644-52
pubmed: 20805332
PLoS Pathog. 2019 Apr 22;15(4):e1007717
pubmed: 31009520
Eukaryot Cell. 2009 Aug;8(8):1235-49
pubmed: 19542310
Microb Ecol. 2012 Jul;64(1):152-61
pubmed: 22318873
Nat Immunol. 2012 Sep;13(9):817-22
pubmed: 22910394
Clin Infect Dis. 2001 Dec 15;33(12):1959-67
pubmed: 11702290
PLoS Negl Trop Dis. 2013;7(2):e2061
pubmed: 23459556