Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer.
Engineering
Environmental, health and safety issues
Journal
Microsystems & nanoengineering
ISSN: 2055-7434
Titre abrégé: Microsyst Nanoeng
Pays: England
ID NLM: 101695458
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
02
2021
revised:
26
11
2021
accepted:
19
12
2021
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Flexible intracerebral probes for neural recording and electrical stimulation have been the focus of many research works to achieve better compliance with the surrounding tissue while minimizing rejection. Strategies have been explored to find the best way to insert flexible probes into the brain while maintaining their flexibility once positioned. Here, we present a novel and versatile scalable batch fabrication approach to deliver ultrathin and flexible probes consisting of a silk-parylene bilayer. The biodegradable silk layer, whose degradation time is programmable, provides a temporary and programmable stiffener to allow the insertion of ultrathin parylene-based flexible devices. Our innovative and robust batch fabrication technology allows complete freedom over probe design in terms of materials, size, shape, and thickness. We demonstrate successful ex vivo insertion of the probe with acute high-fidelity recordings of epileptic seizures in field potentials as well as single-unit action potentials in mouse brain slices. Our novel technological solution for implanting ultraflexible devices in the brain while minimizing rejection risks shows high potential for use in both brain research and clinical therapies.
Identifiants
pubmed: 35251687
doi: 10.1038/s41378-022-00353-7
pii: 353
pmc: PMC8847482
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare no conflict of interest.
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