Calcium Homeostasis in the Epididymal Microenvironment:
GGCX
Tmem16a
Trpv6
calcium homeostasis
epididymis
luminal microenvironment
matrix gla protein (MGP)
sperm maturation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
12
2021
accepted:
19
01
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
In the male reproductive tract, the epididymis is an essential organ for sperm maturation, in which sperm cells acquire mobility and the ability to fertilize oocytes while being stored in a protective microenvironment. Epididymal function involves a specialized luminal microenvironment established by the epithelial cells of epididymal mucosa. Low-calcium concentration is a unique feature of this epididymal luminal microenvironment, its relevance and regulation are, however, incompletely understood. In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related γ-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation. An SNP in the human
Identifiants
pubmed: 35252193
doi: 10.3389/fcell.2022.827940
pii: 827940
pmc: PMC8893953
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
827940Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Shum, Zhang, Cao, Zhou, Shi, Zhang, Gu and Shi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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