Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response.
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
03
2021
revised:
30
11
2021
accepted:
09
02
2022
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
5
4
2022
Statut:
epublish
Résumé
C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections. Activation of the CLEC5A receptor with pathogen-derived antigens leads to a secretion of proinflammatory mediators such as TNF-
Identifiants
pubmed: 35252461
doi: 10.1155/2022/9926305
pmc: PMC8896916
doi:
Substances chimiques
CLEC5A protein, human
0
Cytokines
0
Lectins, C-Type
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9926305Informations de copyright
Copyright © 2022 Milena J. Tosiek et al.
Déclaration de conflit d'intérêts
MJT, KG, AP, and EB are regular employees of Boehringer Ingelheim Pharma GmbH & Co. KG. The authors have no financial or other conflicts to declare.
Références
J Virol. 2016 Dec 16;91(1):
pubmed: 27795434
J Immunother Cancer. 2019 May 28;7(1):140
pubmed: 31138333
J Immunol. 2016 Apr 15;196(8):3227-31
pubmed: 26927798
J Immunol. 2017 Mar 1;198(5):2070-2081
pubmed: 28093525
Sci Rep. 2016 Aug 26;6:32000
pubmed: 27561946
Front Cell Dev Biol. 2021 Oct 12;9:746932
pubmed: 34712666
J Cell Biochem. 2019 Mar;120(3):2756-2765
pubmed: 30270458
Life Sci. 2019 May 1;224:222-231
pubmed: 30928403
PLoS Pathog. 2012;8(4):e1002655
pubmed: 22536153
J Leukoc Biol. 2009 Mar;85(3):508-17
pubmed: 19074552
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
Blood. 2013 Jan 3;121(1):95-106
pubmed: 23152543
Adv Exp Med Biol. 2020;1204:57-73
pubmed: 32152943
PLoS One. 2014 Jan 21;9(1):e86105
pubmed: 24465901
J Immunol Res. 2020 Apr 23;2020:9473497
pubmed: 32377540
J Clin Invest. 2011 Nov;121(11):4446-61
pubmed: 22005300
Immunobiology. 2014 Sep;219(9):695-703
pubmed: 24916404
PLoS One. 2016 Nov 10;11(11):e0166474
pubmed: 27832191
Biochem Biophys Res Commun. 2020 Apr 9;524(3):656-662
pubmed: 32033754
J Comput Biol. 2020 Jul;27(7):1104-1114
pubmed: 31725318
Cancer Gene Ther. 2020 Sep;27(9):669-679
pubmed: 31591460
Nat Commun. 2019 Jun 3;10(1):2402
pubmed: 31160588
J Exp Med. 2010 Mar 15;207(3):579-89
pubmed: 20212065
Mol Immunol. 2011 Jan;48(4):714-9
pubmed: 21094529
Nat Commun. 2017 Aug 21;8(1):299
pubmed: 28824166
J Leukoc Biol. 2015 Oct;98(4):453-66
pubmed: 25877931
Science. 2014 Nov 28;346(6213):1258096
pubmed: 25430774
Immunobiology. 2008;213(9-10):701-13
pubmed: 18926286
Nature. 2008 May 29;453(7195):672-6
pubmed: 18496526