Thymoquinone Induces Nrf2 Mediated Adaptive Homeostasis: Implication for Mercuric Chloride-Induced Nephrotoxicity.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
01 Mar 2022
Historique:
received: 03 01 2022
accepted: 04 02 2022
entrez: 7 3 2022
pubmed: 8 3 2022
medline: 8 3 2022
Statut: epublish

Résumé

the primary function of the kidney is to eliminate metabolic waste products and xenobiotics from the circulation. During this process, the kidney may become vulnerable to toxicity. it was aimed to investigate the impact of thymoquinone (TQ) in mercuric chloride (HgCl HgCl TQ significantly attenuated hazardous effects of HgCl TQ showed protective effects against HgCl

Sections du résumé

BACKGROUND BACKGROUND
the primary function of the kidney is to eliminate metabolic waste products and xenobiotics from the circulation. During this process, the kidney may become vulnerable to toxicity.
OBJECTIVE OBJECTIVE
it was aimed to investigate the impact of thymoquinone (TQ) in mercuric chloride (HgCl
MATERIAL AND METHODS METHODS
HgCl
RESULTS RESULTS
TQ significantly attenuated hazardous effects of HgCl
CONCLUSION CONCLUSIONS
TQ showed protective effects against HgCl

Identifiants

pubmed: 35252727
doi: 10.1021/acsomega.2c00028
pmc: PMC8892676
doi:

Types de publication

Journal Article

Langues

eng

Pagination

7370-7379

Informations de copyright

© 2022 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Références

J Biochem Mol Toxicol. 2003;17(3):161-8
pubmed: 12815612
Biochem Biophys Res Commun. 2018 May 27;500(1):26-34
pubmed: 28676391
Int J Environ Res Public Health. 2010 Jul;7(7):2745-88
pubmed: 20717537
J Postgrad Med. 2011 Jan-Mar;57(1):72-7
pubmed: 21206114
Coord Chem Rev. 2020 Aug 15;417:
pubmed: 32905350
Front Pharmacol. 2021 May 28;12:686614
pubmed: 34122114
Int J Cell Biol. 2010;2010:214074
pubmed: 20182529
Environ Sci Pollut Res Int. 2021 Jun;28(24):31174-31184
pubmed: 33595798
Biotech Histochem. 2020 Nov;95(8):567-574
pubmed: 32207631
Hum Exp Toxicol. 2019 Apr;38(4):482-493
pubmed: 30558456
Biotech Histochem. 2018;93(6):453-462
pubmed: 29701106
Front Pharmacol. 2017 Sep 21;8:656
pubmed: 28983249
Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):109-18
pubmed: 18816292
Pharmaceuticals (Basel). 2017 Dec 23;11(1):
pubmed: 29295496
Metab Brain Dis. 2021 Aug;36(6):1231-1251
pubmed: 33759084
Biochim Biophys Acta. 2008 Apr;1780(4):627-37
pubmed: 18206117
Metab Brain Dis. 2021 Jun;36(5):889-900
pubmed: 33570733
J Toxicol Environ Health A. 2007 May 15;70(10):852-60
pubmed: 17454561
J Biol Chem. 2014 Aug 8;289(32):22413-26
pubmed: 24962574
Toxicology. 2009 Oct 29;264(3):215-24
pubmed: 19720107
Cell Stress Chaperones. 2011 Mar;16(2):143-52
pubmed: 20890773
Drug Discov Ther. 2009 Dec;3(6):296-306
pubmed: 22495664
Chem Biol Interact. 2014 Nov 5;223:102-8
pubmed: 25268985
Toxicol Sci. 2008 Jan;101(1):159-70
pubmed: 17934191
Oxid Med Cell Longev. 2020 Jul 20;2020:3295831
pubmed: 32774669
Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1584-1591
pubmed: 29631058
Int J Biol Macromol. 2014 Apr;65:16-20
pubmed: 24412154
Biol Trace Elem Res. 2016 Mar;170(1):165-72
pubmed: 26226832

Auteurs

Shakila Sabir (S)

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.

Uzma Saleem (U)

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.

Muhammad Sajid Hamid Akash (MSH)

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.

Muhammad Qasim (M)

Department of Bioinformatics and Biotechnology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.

Zunera Chauhdary (Z)

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.

Classifications MeSH