Combination therapy with radiation and hyperthermia-induced clinical complete response of small cell carcinoma of prostate.
clinical complete response
combination therapy
hyperthermia
radiation
small cell carcinoma of prostate
Journal
IJU case reports
ISSN: 2577-171X
Titre abrégé: IJU Case Rep
Pays: Australia
ID NLM: 101764958
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
21
07
2021
accepted:
30
11
2021
entrez:
7
3
2022
pubmed:
8
3
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Small cell carcinoma of the prostate has a poor prognosis even with standard systemic chemotherapy. We report a case, in which combination therapy with radiation and hyperthermia-induced clinical complete response. An 87-year-old man complaining of dysuria was referred to our hospital. Based on magnetic resonance imaging findings and a history of prostate cancer, a prostate biopsy was performed, and small cell carcinoma of the prostate was diagnosed. Whole-pelvis radiation therapy was administered with an additional dose to the prostate; eight cycles of hyperthermia treatment (8 MHz radiofrequency capacitive regional hyperthermia) were administered concurrently. Normalized neuron-specific enolase levels and magnetic resonance imaging confirmed a complete response. A few cancer cells were seen in the post-treatment biopsy specimen, which demonstrated positive immunostaining for heat shock protein 70 and HIKESHI. In this case, small cell carcinoma of the prostate was effectively treated with combined radiation and hyperthermia therapy.
Identifiants
pubmed: 35252794
doi: 10.1002/iju5.12413
pii: IJU512413
pmc: PMC8888022
doi:
Types de publication
Case Reports
Langues
eng
Pagination
113-116Informations de copyright
© 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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