Diagnosis and management of neutropenia in children: The approach of the Study Group on Neutropenia and Marrow Failure Syndromes of the Pediatric Italian Hemato-Oncology Association (Associazione Italiana Emato-Oncologia Pediatrica - AIEOP).

children granulocyte colony-stimulating factor neutropenia neutropenia diagnosis neutropenia therapy

Journal

Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624

Informations de publication

Date de publication:
06 2022
Historique:
revised: 27 01 2022
received: 02 09 2021
accepted: 28 01 2022
pubmed: 8 3 2022
medline: 27 4 2022
entrez: 7 3 2022
Statut: ppublish

Résumé

Neutropenia refers to a group of diseases characterized by a reduction in neutrophil levels below the recommended age threshold. The present study aimed to review the diagnosis and management of neutropenia, including a diagnostic toolkit and candidate underlying genes. This study also aimed to review the progress toward the definition of autoimmune and idiopathic neutropenia rising in infancy or in late childhood but without remission, and provide suggestions for efficient diagnostics, including indications for the bone marrow and genetic testing. The management and treatment protocols for common and unique presentations are also reviewed, providing evidence tailored to a single patient.

Identifiants

pubmed: 35253359
doi: 10.1002/pbc.29599
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e29599

Informations de copyright

© 2022 Wiley Periodicals LLC.

Références

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Auteurs

Francesca Fioredda (F)

Unit of Haematology, IRCCS - Istituto Giannina Gaslini, Genoa, Italy.

Daniela Onofrillo (D)

Pediatric Hematology and Oncology Unit, Department of Hematology, Spirito Santo Hospital, Pescara, Italy.

Piero Farruggia (P)

Department of Pediatric Onco-Hematology, University Hospital, Parma, Italy.

Angelica Barone (A)

Pediatric Hematology and Oncology Unit, ARNAS (Azienda di Rilievo Nazionale ad Alta Specializzazione) Ospedale Civico, Palermo, Italy.

Marinella Veltroni (M)

Department of Pediatric Onco-Hematology, Meyer Children's Hospital, Florence, Italy.

Lucia Dora Notarangelo (LD)

Oncology-Haematology and Bone Marrow Transplantation Unit, Children's Hospital, Brescia, Italy.

Giuseppe Menna (G)

AORN (Azienda Ospedaliera Rilievo Nazionale), Santobono Pausillipon, Naples, Italy.

Giovanna Russo (G)

Pediatric Ematologi and Oncology Unit, Azienda Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.

Baldassarre Martire (B)

Unit of Pediatrics and Neonatology, "Monsignor Dimiccoli" Hospital, Barletta, Italy.

Andrea Finocchi (A)

Unit of Immune and Infectious Disease, University Department of Pediatrics DPUO, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy.
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Federico Verzegnassi (F)

Institute of Maternal and Child Health, IRCCS Burlo Garofalo, Trieste, Italy.
Department of Pediatric Hematology, San Gerardo Hospital, Monza, Italy.

Sonia Bonanomi (S)

MBBM (Monza e Brianza per Bambino e Mamma) Foundation, Department of Pediatrics, University of Milano - Bicocca, Monza, Italy.

Ugo Ramenghi (U)

Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.

Marta Pillon (M)

Pediatric Onco-Hematology Unit, University Hospital of Padua, Padua, Italy.

Carlo Dufour (C)

Unit of Haematology, IRCCS - Istituto Giannina Gaslini, Genoa, Italy.

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