Impact of starting BMI and degree of weight loss on changes in appetite-regulating hormones during diet-induced weight loss.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
17
01
2022
received:
16
09
2021
accepted:
23
01
2022
pubmed:
8
3
2022
medline:
15
4
2022
entrez:
7
3
2022
Statut:
ppublish
Résumé
The aim of this study was to determine whether the hormone changes following weight loss are proportional to the degree of weight loss and to starting BMI. A very low-energy diet was used to achieve 15% weight loss. Fasting and postprandial gut hormones and leptin were measured during a meal test at baseline and at 5% (1%), 10% (2%), and 15% (2.5%) weight loss. Linear mixed-effects models were used to analyze hormone changes. From baseline to 5% weight loss, decreases were seen in fasting concentrations of leptin (-8.25 ng/mL; p < 0.001), amylin (-21.3 pg/mL; p < 0.001), and glucagon-like peptide 1 (-59.55 pg/mL; p < 0.001). There was a small further reduction in leptin between 5% and 15% weight loss (-1.88 ng/mL; p = 0.019) but not in glucagon-like peptide 1 and amylin. Fasting ghrelin showed a significant increase at 10% weight loss (41.64 pg/mL; p = 0.002), with a nonsignificant increase from 10% to 15% loss (26.03 pg/mL; p = 0.065). Postprandial changes in hormone levels were variable. There was no correlation between baseline weight and the degree of hormone changes. The majority of changes in fasting gut hormones and leptin occurred in early weight loss, with minor further changes up to 15% weight loss. Starting weight did not affect the degree of hormone change.
Identifiants
pubmed: 35253406
doi: 10.1002/oby.23404
pmc: PMC9310603
doi:
Substances chimiques
Gastrointestinal Hormones
0
Ghrelin
0
Insulin
0
Islet Amyloid Polypeptide
0
Leptin
0
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
911-919Informations de copyright
© 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
Références
J Clin Endocrinol Metab. 2001 Dec;86(12):5992
pubmed: 11739476
Obes Res. 1999 Mar;7(2):170-8
pubmed: 10102254
Am J Clin Nutr. 1998 Oct;68(4):794-801
pubmed: 9771856
Lancet. 2018 Feb 10;391(10120):541-551
pubmed: 29221645
Cell Metab. 2016 Apr 12;23(4):591-601
pubmed: 26916363
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3577-3582
pubmed: 27736161
Obesity (Silver Spring). 2016 Aug;24(8):1620-9
pubmed: 27460711
Obesity (Silver Spring). 2022 Apr;30(4):911-919
pubmed: 35253406
Nat Med. 2002 Jul;8(7):738-42
pubmed: 12068290
Clin Sci (Lond). 1995 Oct;89(4):375-81
pubmed: 7493437
J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S37-50
pubmed: 18987269
Int J Obes (Lond). 2005 Oct;29(10):1168-74
pubmed: 15925949
Eur J Endocrinol. 1996 Dec;135(6):659-62
pubmed: 9025708
Metabolism. 2009 Aug;58(8):1096-101
pubmed: 19477470
J Clin Endocrinol Metab. 1997 Nov;82(11):3647-54
pubmed: 9360521
N Engl J Med. 2011 Oct 27;365(17):1597-604
pubmed: 22029981
Eur J Clin Nutr. 2013 Jul;67(7):759-64
pubmed: 23632752
Gastroenterology. 2015 Aug;149(2):367-78.e5; quiz e14-5
pubmed: 25865049
J Clin Endocrinol Metab. 2003 Aug;88(8):3989-92
pubmed: 12915697
J Clin Invest. 2008 Jul;118(7):2583-91
pubmed: 18568078
Nature. 2002 Aug 8;418(6898):650-4
pubmed: 12167864
Diabetes Care. 2011 Jul;34(7):1481-6
pubmed: 21593294
Am J Clin Nutr. 2008 Oct;88(4):906-12
pubmed: 18842775
Gut. 1999 Jan;44(1):81-6
pubmed: 9862830
Br J Nutr. 2000 Oct;84(4):405-15
pubmed: 11103211
Transl Behav Med. 2016 Sep;6(3):339-46
pubmed: 27528523
Endocr Pract. 2016 Jul;22(7):842-84
pubmed: 27472012
Obes Facts. 2008;1(2):106-16
pubmed: 20054170
Int J Obes Relat Metab Disord. 2000 Jul;24(7):906-14
pubmed: 10918539
Eur J Endocrinol. 2008 Feb;158(2):179-87
pubmed: 18230824