Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.

Animals Colorectal Neoplasms / pathology Cytokines Homeostasis Mice Mucin-4 / genetics Wnt Signaling Pathway / genetics
MUC4 colorectal cancer intestinal homeostasis mucin

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
07 03 2022
Historique:
received: 04 11 2021
accepted: 21 02 2022
pubmed: 8 3 2022
medline: 26 4 2022
entrez: 7 3 2022
Statut: ppublish

Résumé

Mucins are components of the mucus layer overlying the intestinal epithelial cells, which maintains physiological homeostasis. Altered mucin expression is associated with disease progression. Expression of MUC4 decreases in colorectal cancer (CRC); however, its functional role and implications in the intestinal pathology in CRC are not studied well. Therefore, we generated a genetically engineered Muc4 knockout (Muc4

Identifiants

DOI: 10.18632/aging.203935 PMID: 35255004 PMC: PMC8954958
pubmed: 35255004
pii: 203935
doi: 10.18632/aging.203935
pmc: PMC8954958
doi:

Substances chimiques

Cytokines 0
FAM3D protein, mouse 0
Muc4 protein, mouse 0
Mucin-4 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2025-2046

Subventions

Organisme : BLRD VA
ID : I01 BX004494
Pays : United States

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Auteurs

Ramesh Pothuraju (R)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Priya Pai (P)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Sanjib Chaudhary (S)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Jawed A Siddiqui (JA)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Jesse L Cox (JL)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Sukhwinder Kaur (S)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Satyanarayana Rachagani (S)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Hemant K Roy (HK)

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Michael Bouvet (M)

Division of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.
VA San Diego Healthcare System, San Diego, CA 92161, USA.

Surinder K Batra (SK)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Mucine-4 › Depletion of transmembrane mucin 4 (Muc4)...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Depletion of transmembrane mucin 4 (Muc4)...