Microbiota medicine: towards clinical revolution.
Built environment microbiome
Dysbiosis
Fecal microbiota transplant
Metabolic syndrome
Metabolites
Oral microbiota
Prebiotics
Probiotics
miRNAs
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
07 03 2022
07 03 2022
Historique:
received:
12
01
2022
accepted:
03
02
2022
entrez:
8
3
2022
pubmed:
9
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption and protecting the body against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between gut microbiota and many organs within the human body such as the intestines, the lungs, the brain, and the skin. Large body of evidence demonstrated, more than a decade ago, that the gut microbial alteration is a key factor in the pathogenesis of many local and systemic disorders. In this regard, a deep understanding of the mechanisms involved in the gut microbial symbiosis/dysbiosis is crucial for the clinical and health field. We review the most recent studies on the involvement of gut microbiota in the pathogenesis of many diseases. We also elaborate the different strategies used to manipulate the gut microbiota in the prevention and treatment of disorders. The future of medicine is strongly related to the quality of our microbiota. Targeting microbiota dysbiosis will be a huge challenge.
Identifiants
pubmed: 35255932
doi: 10.1186/s12967-022-03296-9
pii: 10.1186/s12967-022-03296-9
pmc: PMC8900094
doi:
Substances chimiques
Prebiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111Informations de copyright
© 2022. The Author(s).
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