The effect of low flow anesthesia with sevoflurane on oxidative status: A prospective, randomized study.
low-flow anesthesia
oxidative status
sevoflurane
thiol/disulfide homeostasis
Journal
Saudi medical journal
ISSN: 1658-3175
Titre abrégé: Saudi Med J
Pays: Saudi Arabia
ID NLM: 7909441
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
29
10
2021
accepted:
08
02
2022
entrez:
8
3
2022
pubmed:
9
3
2022
medline:
11
3
2022
Statut:
ppublish
Résumé
To assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery. The study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min Disulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values. It was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.
Identifiants
pubmed: 35256489
pii: 43/3/227
doi: 10.15537/smj.2022.43.3.20210876
pmc: PMC9280541
doi:
Substances chimiques
Disulfides
0
Sevoflurane
38LVP0K73A
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-235Informations de copyright
Copyright: © Saudi Medical Journal.
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