Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling.
Analgesics, Opioid
/ adverse effects
Animals
Drug Tolerance
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
/ pharmacology
Gastrointestinal Tract
Hyperalgesia
/ chemically induced
Male
Mice
Mice, Inbred C57BL
Morphine
/ pharmacology
Narcotic Antagonists
/ pharmacology
Protein Kinase C
Receptors, Opioid
Receptors, Opioid, mu
Signal Transduction
colonic afferent nerves
delta-opioid receptor
dorsal root ganglia
mu-opioid receptor
opioid tolerance
opioid-induced hyperalgesia
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
20 04 2022
20 04 2022
Historique:
received:
11
10
2021
revised:
22
02
2022
accepted:
23
02
2022
pubmed:
9
3
2022
medline:
23
4
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
Opioid tolerance (OT) leads to dose escalation and serious side effects, including opioid-induced hyperalgesia (OIH). We sought to better understand the mechanisms underlying this event in the gastrointestinal tract. Chronic
Identifiants
pubmed: 35256532
pii: JNEUROSCI.2098-21.2022
doi: 10.1523/JNEUROSCI.2098-21.2022
pmc: PMC9034783
doi:
Substances chimiques
Analgesics, Opioid
0
Narcotic Antagonists
0
Receptors, Opioid
0
Receptors, Opioid, mu
0
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
100929-53-1
Morphine
76I7G6D29C
Protein Kinase C
EC 2.7.11.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3316-3328Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102722
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
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