A Diverse Spectrum of Immune Complex- and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma.
MGRS
Mantle cell lymphoma
glomerulonephritis
kidney biopsy
lymphoma
renal pathology
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
06
12
2021
accepted:
13
12
2021
entrez:
8
3
2022
pubmed:
9
3
2022
medline:
9
3
2022
Statut:
epublish
Résumé
There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48-87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had immune complex (IC) or complement-mediated (C3) disease including proliferative glomerulonephritis (GN) with monotypic Ig deposits (PGNMID [2]), C3GN, (2), secondary membranous nephropathy (MN [3]), tubular basement membrane (TBM) deposits (2), and modest lupus-like GN (2). Lymphomatous infiltration was present in 8 of the 20 patients, 5 with coincident IC or C3 lesions. A total of 6 patients with available follow-up were treated for MCL, all with clinical remission of GN (2 PGNMID, 2 C3GN, and 2 MN). MCL is associated with diverse monoclonal and polyclonal glomerular and extra-glomerular IC and C3 disease. For patients with active MCL and kidney dysfunction requiring biopsy, 70% had findings due or potentially due to lymphoma, including 55% with IC or C3 disease and 40% had lymphomatous kidney infiltration. IC and C3GN in the setting of active MCL was responsive to lymphoma-directed therapy.
Identifiants
pubmed: 35257069
doi: 10.1016/j.ekir.2021.12.020
pii: S2468-0249(21)01610-7
pmc: PMC8897291
doi:
Types de publication
Journal Article
Langues
eng
Pagination
568-579Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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