Cytologic features of reactive fibroplasia in cutaneous and subcutaneous lesions of dogs: A retrospective study.
cytology
fibroplasia
inflammation
sarcoma
spindle cells
Journal
Veterinary clinical pathology
ISSN: 1939-165X
Titre abrégé: Vet Clin Pathol
Pays: United States
ID NLM: 9880575
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
06
10
2021
received:
16
07
2021
accepted:
07
10
2021
pubmed:
9
3
2022
medline:
7
6
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
Determining reactive fibroplasia from primary neoplastic proliferation can be difficult using the cytologic features of spindle cells. This study aimed to describe qualitative features of benign reactive spindle cells and provide a diagnostic tool to distinguish between fibroplasia and soft tissue sarcoma. Cytologic samples from cutaneous lesions with histopathologically confirmed fibroplasia were reviewed and compared with cytologic samples from confirmed low-grade soft tissue sarcomas. The samples were obtained from the Archive of the Laboratorio Veterinario Bresciano (Brescia; Italy). A total of 25 cytologic samples retrieved from the database fit the selection criteria. For comparison, 25 cytologic samples of histopathologically confirmed soft tissue sarcomas with secondary inflammation were obtained and reviewed from the same database. A low number of singularly distributed spindle cells with mild features of atypia and a high ratio of inflammatory to spindle cells was observed in confirmed cases of fibroplasia. Low cellularity, individualized spindle cells, and an increased inflammatory-to-spindle cell ratio were more indicative of fibroplasia than sarcoma.
Sections du résumé
BACKGROUND
BACKGROUND
Determining reactive fibroplasia from primary neoplastic proliferation can be difficult using the cytologic features of spindle cells.
OBJECTIVES
OBJECTIVE
This study aimed to describe qualitative features of benign reactive spindle cells and provide a diagnostic tool to distinguish between fibroplasia and soft tissue sarcoma.
METHODS
METHODS
Cytologic samples from cutaneous lesions with histopathologically confirmed fibroplasia were reviewed and compared with cytologic samples from confirmed low-grade soft tissue sarcomas. The samples were obtained from the Archive of the Laboratorio Veterinario Bresciano (Brescia; Italy).
RESULTS
RESULTS
A total of 25 cytologic samples retrieved from the database fit the selection criteria. For comparison, 25 cytologic samples of histopathologically confirmed soft tissue sarcomas with secondary inflammation were obtained and reviewed from the same database. A low number of singularly distributed spindle cells with mild features of atypia and a high ratio of inflammatory to spindle cells was observed in confirmed cases of fibroplasia.
CONCLUSIONS
CONCLUSIONS
Low cellularity, individualized spindle cells, and an increased inflammatory-to-spindle cell ratio were more indicative of fibroplasia than sarcoma.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
244-251Informations de copyright
© 2022 American Society for Veterinary Clinical Pathology.
Références
Meinkoth JH, Cowell RL, Tyler RD. Cell type s and criteria of malignancy. In: Valenciano AC, Cowell RL, eds. Diagnostic Cytology and Hematology of the Dog and Cat. IVth ed. St. Louis, MO: Elsevier; 2014:20-47.
Ackermann RM. Chronic inflammation and wound healing. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Diseases. IV ed. St. Louis, MO: Mosby Elsevier; 2007:163-164.
Kusewitt DF, Rush LJ. Neoplasia and tumor biology. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Diseases. IV ed. St. Louis, MO: Mosby Elsevier; 2007:271-272.
Raskin RE. General categories of cytologic interpretation. In: Raskin RE, Meyer DJ, eds. Canine and Feline Cytology-A Color Atlas and Interpretation Guide. IIIrd ed. St. Louis, MO: Elsevier; 2016:23-24.
Cullen JM, Breen M. An overview of molecular cancer pathogenesis, prognosis and diagnosis. In: Meuten DJ, ed. Tumors in Domestic Animals. Vth ed. Ames, IA: John Wiley & Sons Inc.; 2017:12-13.
Raskin RE. Skin and Subutaneous tissues. In: Raskin RE, Meyer DJ, eds. Canine and Feline Cytology-A Color Atlas and Interpretation Guide. IIIrd ed. St. Louis, MO: Elsevier; 2016:78-79.
Meinkhot JH, Cowell RL, Tyler RD. Cell types and criteria of malignancy. In: Valenciano AC, Cowell RL, eds. Diagnostic Cytology and Hematology of the Dog and Cat. IVth ed. St. Louis, MO: Elsevier; 2014:38-39.
Mair S, Dunbar F, Becker PJ, Du Plessis W. Fine needle cytology-is aspiration suction necessary? A study of 100 masses in various sites. Acta Cytol 1989;33:809-813
Yue XH, Zheng SF. Cytologic diagnosis by transthoracic fine needle sampling without aspiration. Acta Cytol. 1989;33:805-808.
Fisher DJ. Cutaneous and subcutaneous lesions. In: Valenciano AC, Cowell RL, eds. Diagnostic Cytology and Hematology of the Dog and Cat. IVth ed. St. Louis, MO: Elsevier; 2014:103-104.
Kuntz CA, Dernell WS, Powers BE, Devitt C, Straw RC, Withrow SJ. Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986-1996). J Am Vet Med Assoc. 1997;211:1147-1151.
James LP. Cytopathology of mesenchymal repair. Diagn Cytopathol. 1985;1:91-104.
Kilpatrick SE, Geisinger KR. Soft tissue sarcomas-the usefulness and limitations of fine-needle aspiration biopsy. Am J Clin Path. 1998;110:50-68.
Steinberg JD, Keating J. Soft tissue sarcomas. In: Sharkey LC, Radin MJ, Seelig D, eds. Veterinary Cytology. Hoboken, NJ: Wiley Blackwell; 2021:166-167.
Raposo TP, Beirão BCB, Pang LY, Queiroga FL, Argyle DJ. Inflammation and cancer: till death tears them apart. Vet J. 2015 Aug;205:161-174.
Brazzell JL, Heinrich D, Walz JZ. Dermal and subcutaneous masses. In: Sharkey LC, Seelig D, Radin J, eds. Veterinary Cytology. Hoboken, NJ: Wiley Blackwell; 2021:125-126.
Dolly JH, David WG. Multinucleated giant cells from fibroblast cultures. Biomaterials. 2011;32:3977-3987.
Avallone G, Helmbold P, Caniatti M, Stefanello D, Nayak RC, Roccabianca P. The spectrum of canine cutaneous perivascular wall tumors: morphologic, phenotypic and clinical characterization. Vet Path 2007 Sep;44:607-20.
Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Fibrous tumor. In: Gross TL, Ihrke PJ, Walder EJ, Affolter VK, eds. Skin Diseases of the Dog and Cat. IIth ed. Ames, IA: Blackwell; 2005:722-723.
Giatromanolaki A, Sivridis E, Koukourakis MI. The pathology of tumor stromatogenesis. Cancer Biol Ther. 2007;6:639-645.