Psychopharmacology: past, present and future.
Journal
International clinical psychopharmacology
ISSN: 1473-5857
Titre abrégé: Int Clin Psychopharmacol
Pays: England
ID NLM: 8609061
Informations de publication
Date de publication:
01 05 2022
01 05 2022
Historique:
pubmed:
9
3
2022
medline:
5
4
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
The origin of modern psychopharmacology dates to the 50s, with the discovery of imipramine and chlorpromazine. At present, we can choose among over 100 different compounds, which are effective in many psychiatric disturbances but are far from perfect in terms of efficacy and tolerability. The main limitation of available treatments is their lack in specificity, both in terms of pharmacologic targets and regional brain specificity. Several new compounds with innovative mechanisms of action have been recently approved; however, pharmacologic treatments targeted for specific tissues are still not available. Recent imaging and genetic findings suggest that we may be close to discovering the regional pathophysiologic mechanisms of psychiatric disorders. Targeted treatment to specific proteins or even genes may be possible using monoclonal antibodies, RNA silencing, gene editing or drug repurposing. We may be therefore close to a shift of paradigm in the treatment of psychiatric disorders, with innovative and targeted treatments.
Identifiants
pubmed: 35258034
doi: 10.1097/YIC.0000000000000402
pii: 00004850-202205000-00003
doi:
Substances chimiques
Imipramine
OGG85SX4E4
Chlorpromazine
U42B7VYA4P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-83Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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