Role of the splenic microenvironment in chronic lymphocytic leukemia development in Eµ-TCL1 transgenic mice.
Cell lines and animal models
basic biology
cytokine production and paraneoplastic conditions
lymphocytes
lymphoid leukemia
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
9
3
2022
medline:
19
8
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
The chronic lymphocytic leukemia (CLL) microenvironment has been receiving an increasing amount of attention, but there is currently limited data surrounding how the microenvironment affects initial development of CLL. We determined that the spleen is the initial site of CLL growth through monitoring of transgenic Eμ-TCL1 mice that develop CLL. Subsequently, we isolated stromal cells from the spleens of Eμ-TCL1 mice (EMST cells) that induce CLL cell division
Identifiants
pubmed: 35258388
doi: 10.1080/10428194.2022.2045596
doi:
Substances chimiques
Proto-Oncogene Proteins
0
Tcl1 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1810-1822Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001998
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA239480
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA165469
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA177558
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000117
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA165990
Pays : United States