Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
04 04 2022
04 04 2022
Historique:
received:
29
09
2021
revised:
22
12
2021
accepted:
24
01
2022
entrez:
8
3
2022
pubmed:
9
3
2022
medline:
3
5
2022
Statut:
ppublish
Résumé
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the capsules enhance bacterial virulence under in vivo infection conditions. Here we show that the capsules primarily target the liver to enhance bacterial survival at the onset of blood-borne infections. In a mouse sepsis model, the capsules enabled human pathogens Streptococcus pneumoniae and Escherichia coli to circumvent the recognition of liver-resident macrophage Kupffer cells (KCs) in a capsular serotype-dependent manner. In contrast to effective capture of acapsular bacteria by KCs, the encapsulated bacteria are partially (low-virulence types) or completely (high-virulence types) "untouchable" for KCs. We finally identified the asialoglycoprotein receptor (ASGR) as the first known capsule receptor on KCs to recognize the low-virulence serotype-7F and -14 pneumococcal capsules. Our data identify the molecular interplay between the capsules and KCs as a master controller of the fate and virulence of encapsulated bacteria, and suggest that the interplay is targetable for therapeutic control of septic infections.
Identifiants
pubmed: 35258552
pii: 213054
doi: 10.1084/jem.20212032
pmc: PMC8908791
pii:
doi:
Substances chimiques
Capsules
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 An et al.
Déclaration de conflit d'intérêts
Disclosures: M.R. Oggioni has a PhD student jointly with GSK Vaccines working on the pathogenesis of pneumonia (BBSRC grant BB/S507052/1). No other disclosures were reported.
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