Prepulse inhibition deficits in inbred and outbred rats and between-strain differences in startle habituation do not depend on startle reactivity levels.
Animal model
Inbred rats
Outbred rats
Prepulse inhibition
Schizophrenia
Sensorimotor gating
Startle habituation
Startle reactivity
Journal
Behavioural processes
ISSN: 1872-8308
Titre abrégé: Behav Processes
Pays: Netherlands
ID NLM: 7703854
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
19
05
2021
revised:
01
02
2022
accepted:
03
03
2022
pubmed:
9
3
2022
medline:
6
4
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
The acoustic startle response and prepulse inhibition (PPI) of startle are measures related to information processing, which is impaired in schizophrenia. Some studies have provided inconclusive patterns of association between both measures in rodents. We assessed the influence of baseline startle response on PPI in large samples of Roman high-(RHA) and low-avoidance (RLA) rat strains and in genetically heterogeneous stock (HS) rats. Results show that RHAs exhibit a PPI deficit compared to RLA rats, which is present regardless of the startle response levels. HS rats were stratified in two sub-samples according to their high or low PPI (HS-highPPI or HS-lowPPI, respectively) scores, and then they were grouped by their differential baseline startle amplitude (high reactivity -HR- or low reactivity -LR-) within each sub-sample. Differences between high- and low-PPI-stratified HS rats remained regardless of their high or low startle amplitude scores. Thus, the impairments in %PPI found in both RHA and HS-LowPPI rats are present irrespective of the relatively high or low levels of startle amplitude in pulse-alone trials. Another objective of the present study was to evaluate whether habituation to the startling stimulus (i.e., pulse) depends on the initial baseline startle response. RLA rats habituated to the startling stimulus more effectively than RHAs regardless of their baseline startle responses. Conversely, there were no differences in startle habituation in the HS rats grouped by their extreme scores of baseline startle. Altogether, these findings suggest a deficit in information processing in RHA rats, which along with evidence indicating that this strain displays other attentional/cognitive impairments, strengthens the validity of the RHA strain as a putative model of schizophrenia-relevant features.
Identifiants
pubmed: 35259448
pii: S0376-6357(22)00035-3
doi: 10.1016/j.beproc.2022.104618
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104618Informations de copyright
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